细胞质 mRNA 定位的控制。
Control of cytoplasmic mRNA localization.
机构信息
Department of Biochemistry, Université de Montréal, 2900 Edouard-Montpetit, Montréal, Qc, Canada.
出版信息
Cell Mol Life Sci. 2012 Feb;69(4):535-52. doi: 10.1007/s00018-011-0814-3. Epub 2011 Oct 8.
Abstract
mRNA localization is a mechanism used by various organisms to control the spatial and temporal production of proteins. This process is a highly regulated event that requires multiple cis- and trans-acting elements that mediate the accurate localization of target mRNAs. The intrinsic nature of localization elements, together with their interaction with different RNA-binding proteins, establishes control mechanisms that can oversee the transcript from its birth in the nucleus to its specific final destination. In this review, we aim to summarize the different mechanisms of mRNA localization, with a particular focus on the various control mechanisms that affect the localization of mRNAs in the cytoplasm.
摘要
mRNA 定位是各种生物体用来控制蛋白质时空产生的一种机制。这个过程是一个高度调控的事件，需要多个顺式和反式作用元件来介导靶 mRNA 的精确定位。定位元件的内在性质，以及它们与不同 RNA 结合蛋白的相互作用，建立了可以从核内转录本的产生到其特定最终目的地进行监督的控制机制。在这篇综述中，我们旨在总结 mRNA 定位的不同机制，特别关注影响细胞质中 mRNA 定位的各种控制机制。
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本文引用的文献
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