Mockenhaupt Stefan, Makeyev Eugene V
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore.
School of Biological Sciences, Nanyang Technological University, Singapore 637551, Singapore; MRC Centre for Developmental Neurobiology, King's College London, London SE1 1UL, UK.
Semin Cell Dev Biol. 2015 Dec;47-48:32-9. doi: 10.1016/j.semcdb.2015.10.018. Epub 2015 Oct 19.
A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo alternative splicing to generate more than one mature product. By targeting the open reading frame region this process increases diversity of protein isoforms beyond the nominal coding capacity of the genome. However, alternative splicing also frequently controls output levels and spatiotemporal features of cellular and organismal gene expression programs. Here we discuss how these non-coding functions of alternative splicing contribute to development through regulation of mRNA stability, translational efficiency and cellular localization.
大多数高等真核生物中的信使核糖核酸前体（前体mRNA）会经历可变剪接，以产生不止一种成熟产物。通过靶向开放阅读框区域，这一过程增加了蛋白质异构体的多样性，超出了基因组的名义编码能力。然而，可变剪接也经常控制细胞和机体基因表达程序的输出水平及时空特征。在此，我们讨论可变剪接的这些非编码功能如何通过调节mRNA稳定性、翻译效率及细胞定位来促进发育。
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