Molécules de Communication et Adaptation des Micro-Organismes, UMR 7245 CNRS, Muséum National d'Histoire Naturelle, 63 rue Buffon 75005 Paris, France.
J Nat Prod. 2011 Oct 28;74(10):2286-9. doi: 10.1021/np2004825. Epub 2011 Oct 10.
From the results of an ethnomedicinal investigation of plants from Uganda with antimalarial activity, Citropsis articulata was selected because of the antiplasmodial effect of an ethyl acetate extract of its root bark. Thus, from the cyclohexane, ethyl acetate, and methanol extracts, two new heterocyclic compounds, omubioside (1) and katimborine (2), were isolated in addition to five known coumarins (rutarin (3), seselin (4), suberosin (5), demethylsuberosin (6), and haploperoside (7)), two known alkaloids (5-hydroxynoracronycine (8) and 1,5-dihydroxy-2,3-dimethoxy-10-methyl-9-acridone (9)), trigonelline (10), and the limonoid 7α-obacunyl acetate (11). The best growth inhibitors of Plasmodium falciparum were alkaloids 8 and 9, with IC50 values of 0.9 and 3.0 μg/mL.
从具有抗疟活性的乌干达植物的民族医学研究结果中，选择了 Citropsis articulata，因为其根皮的乙酸乙酯提取物具有抗疟原虫作用。因此，从环己烷、乙酸乙酯和甲醇提取物中分离出两种新的杂环化合物，奥木比奥昔德（1）和卡提莫林（2），以及五种已知的香豆素（rutarin（3）、seselin（4）、suberosin（5）、demethylsuberosin（6）和haploperoside（7））、两种已知的生物碱（5-羟基诺拉西丁（8）和 1,5-二羟基-2,3-二甲氧基-10-甲基-9-吖啶酮（9））、三叶草碱（10）和 limonoid 7α-obacunyl 乙酸酯（11）。对疟原虫生长抑制作用最好的是生物碱 8 和 9，其 IC50 值分别为 0.9 和 3.0 μg/mL。
