生物活性喹啉和喹唑啉生物碱 第二部分。
Biologically active quinoline and quinazoline alkaloids part II.
机构信息
Key Laboratory of Veterinary Pharmaceutical Development of Ministry of Agriculture, Key Laboratory of New Animal Drug Project, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
School of Pharmacy, Lanzhou University, Lanzhou, P.R. China.
出版信息
Med Res Rev. 2018 Sep;38(5):1614-1660. doi: 10.1002/med.21492. Epub 2018 Feb 27.
Abstract
To follow-up on our prior Part I review, this Part II review summarizes and provides updated literature on novel quinoline and quinazoline alkaloids isolated during the period of 2009-2016, together with the biological activity and the mechanisms of action of these classes of natural products. Over 200 molecules with a broad range of biological activities, including antitumor, antiparasitic and insecticidal, antibacterial and antifungal, cardioprotective, antiviral, anti-inflammatory, hepatoprotective, antioxidant, anti-asthma, antitussive, and other activities, are discussed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.
摘要
承接我们之前的第一部分综述，这第二部分综述总结并提供了 2009 年至 2016 年期间分离出的新型喹啉和喹唑啉生物碱的最新文献，以及这些天然产物的生物活性和作用机制。讨论了超过 200 种具有广泛生物活性的分子，包括抗肿瘤、抗寄生虫和杀虫、抗菌和抗真菌、心脏保护、抗病毒、抗炎、保肝、抗氧化、抗哮喘、镇咳等活性。本综述应该为从原始天然存在的喹啉和喹唑啉生物碱中发现新的更好的药物提供新的线索或可能性。
相似文献
1
Biologically active quinoline and quinazoline alkaloids part II.
Med Res Rev. 2018 Sep;38(5):1614-1660. doi: 10.1002/med.21492. Epub 2018 Feb 27.
2
Biologically active quinoline and quinazoline alkaloids part I.
Med Res Rev. 2018 May;38(3):775-828. doi: 10.1002/med.21466. Epub 2017 Sep 13.
3
Biology of quinoline and quinazoline alkaloids.
Alkaloids Chem Biol. 2022;88:1-47. doi: 10.1016/bs.alkal.2021.08.002. Epub 2022 Jan 19.
4
Novel quinazoline-quinoline alkaloids with cytotoxic and DNA topoisomerase II inhibitory activities.
Bioorg Med Chem Lett. 2004 Mar 8;14(5):1193-6. doi: 10.1016/j.bmcl.2003.12.048.
5
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 1999 Dec;16(6):697-709. doi: 10.1039/a809408j.
6
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 2004 Oct;21(5):650-68. doi: 10.1039/b310691h. Epub 2004 Sep 14.
7
Biologically active isoquinoline alkaloids covering 2014-2018.
Med Res Rev. 2020 Nov;40(6):2212-2289. doi: 10.1002/med.21703. Epub 2020 Jul 29.
8
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 2002 Dec;19(6):742-60. doi: 10.1039/b104971m.
9
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 2003 Oct;20(5):476-93. doi: 10.1039/b208140g.
10
Quinoline, quinazoline and acridone alkaloids.
Nat Prod Rep. 2007 Feb;24(1):223-46. doi: 10.1039/b509528j. Epub 2007 Jan 3.
引用本文的文献
1
Quinazolines []-Annelated by Five-Membered Heterocycles: Synthesis and Biological Activity.
Molecules. 2025 Aug 27;30(17):3506. doi: 10.3390/molecules30173506.
2
4(3)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery.
Int J Mol Sci. 2025 Mar 10;26(6):2473. doi: 10.3390/ijms26062473.
3
Antibacterial and antioxidant potentials, detection of host origin compounds, and metabolic profiling of endophytic Bacillus spp. isolated from Rauvolfia serpentina (L.) Benth. ex Kurz.
Sci Rep. 2025 Jan 15;15(1):2094. doi: 10.1038/s41598-024-84893-0.
4
Antibacterial Activity and Antifungal Activity of Monomeric Alkaloids.
Toxins (Basel). 2024 Nov 12;16(11):489. doi: 10.3390/toxins16110489.
5
Diversity oriented total synthesis (DOTS) of pyridoquinazolinone alkaloids and their analogues.
Tetrahedron Chem. 2024 Mar;9. doi: 10.1016/j.tchem.2024.100062. Epub 2024 Jan 19.
6
Critical view on antimicrobial, antibiofilm and cytotoxic activities of quinazolin-4(3)-one derived schiff bases and their Cu(II) complexes.
Heliyon. 2024 Apr 2;10(7):e29051. doi: 10.1016/j.heliyon.2024.e29051. eCollection 2024 Apr 15.
7
Uncovering the potentiality of quinazoline derivatives against Pseudomonas aeruginosa with antimicrobial synergy and SAR analysis.
J Antibiot (Tokyo). 2024 Jun;77(6):365-381. doi: 10.1038/s41429-024-00717-3. Epub 2024 Mar 21.
8
Comprehensive Analysis of 11 Species of (Rutaceae) by Untargeted LC-IT-TOF/MS Metabolomics and In Vitro Functional Methods.
Molecules. 2024 Feb 28;29(5):1059. doi: 10.3390/molecules29051059.
9
Chemical Constituents and Bioactivities of the Plant-Derived Fungus .
Molecules. 2024 Jan 30;29(3):649. doi: 10.3390/molecules29030649.
10
Phytochemistry Profile, Antimicrobial and Antitumor Potential of the Methanolic Extract of A DC and NEES.
Evid Based Complement Alternat Med. 2024 Jan 3;2024:5513141. doi: 10.1155/2024/5513141. eCollection 2024.
本文引用的文献
1
Intramolecular Hydrogen Bonds in Conformers of Quinine and Quinidine: An HF, MP2 and DFT Study.
Molecules. 2017 Feb 7;22(2):245. doi: 10.3390/molecules22020245.
2
In vitro anti-MRSA activity of Couroupita guianensis extract and its component Tryptanthrin.
Nat Prod Res. 2017 Sep;31(17):2077-2080. doi: 10.1080/14786419.2016.1272110. Epub 2016 Dec 26.
3
Versiquinazolines A-K, Fumiquinazoline-Type Alkaloids from the Gorgonian-Derived Fungus Aspergillus versicolor LZD-14-1.
J Nat Prod. 2016 Nov 23;79(11):2941-2952. doi: 10.1021/acs.jnatprod.6b00801. Epub 2016 Nov 10.
4
Quinoline Alkaloids Isolated from Choisya Aztec-Pearl and Their Contribution to the Overall Antinociceptive Activity of This Plant.
PLoS One. 2016 Oct 21;11(10):e0164998. doi: 10.1371/journal.pone.0164998. eCollection 2016.
5
Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect.
Int J Mol Sci. 2016 Sep 28;17(10):1648. doi: 10.3390/ijms17101648.
6
Furoquinoline Alkaloids and Methoxyflavones from the Stem Bark of Melicope madagascariensis (Baker) T.G. Hartley.
Nat Prod Bioprospect. 2016 Oct;6(5):261-265. doi: 10.1007/s13659-016-0106-6. Epub 2016 Sep 21.
7
Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks.
J Nat Prod. 2016 Sep 23;79(9):2270-8. doi: 10.1021/acs.jnatprod.6b00379. Epub 2016 Aug 24.
8
Microwave-assisted extraction of three bioactive alkaloids from Peganum harmala L. and their acaricidal activity against Psoroptes cuniculi in vitro.
J Ethnopharmacol. 2016 Nov 4;192:350-361. doi: 10.1016/j.jep.2016.07.057. Epub 2016 Jul 22.
9
Suppression of tumor cell proliferation by quinine via the inhibition of the tumor necrosis factor receptor‑associated factor 6‑AKT interaction.
Mol Med Rep. 2016 Sep;14(3):2171-9. doi: 10.3892/mmr.2016.5492. Epub 2016 Jul 11.
10
Effect of Glycosin alkaloid from Rhizophora apiculata in non-insulin dependent diabetic rats and its mechanism of action: In vivo and in silico studies.
Phytomedicine. 2016 Jun 1;23(6):632-40. doi: 10.1016/j.phymed.2016.03.004. Epub 2016 Mar 24.
Zotero 插件