School of Dentistry, University of Ribeirao Preto (UNAERP), Ribeirao Preto, Sao Paulo Department of Stomatology, A. C. Camargo Hospital, Sao Paulo.
Int Endod J. 2012 Mar;45(3):209-14. doi: 10.1111/j.1365-2591.2011.01961.x. Epub 2011 Oct 11.
To evaluate parathyroid hormone/parathyroid hormone-related peptide receptor 1 (PTHR1) expression in odontogenic cystic lesions and to compare immunoexpression between the lesions.
Thirty-five radicular cysts, 22 dentigerous cysts and 17 keratocystic odontogenic tumours were evaluated. Immunohistochemical reactions against PHTR1 were carried out in 3-μm histological sections, and the expression and the intensity of PTHR1 expression were evaluated. For statistical analysis, the Fisher exact test was used, with a significance of 5%.
The intensity of expression in the epithelial lining was significantly weaker in the radicular cyst (P = 0.007). However, in the fibrous capsule, the radicular cyst presented higher positivity for PTHR1 (P = 0.04).
The probable co-expression of PTHrP and PTHR1 in odontogenic cystic lesions may eventually have an autocrine and/or paracrine stimulus in the epithelial and mesenchymal cells, inducing proliferation and lesion growth.
评估牙源性囊性病变中甲状旁腺激素/甲状旁腺激素相关肽受体 1 (PTHR1) 的表达，并比较病变之间的免疫表达。
评估了 35 例根囊肿、22 例含牙囊肿和 17 例角化囊性牙源性肿瘤。对 PTHTR1 进行了 3μm 组织切片的免疫组织化学反应，评估了 PTHR1 表达的表达和强度。统计学分析采用 Fisher 确切检验，显著性水平为 5%。
在牙源性囊肿的上皮衬里中，表达强度显著较弱（P = 0.007）。然而，在纤维囊内，根囊肿对 PTHR1 的阳性率更高（P = 0.04）。
牙源性囊性病变中 PTHrP 和 PTHR1 的可能共表达可能最终在上皮细胞和间充质细胞中产生自分泌和/或旁分泌刺激，诱导增殖和病变生长。
