The Dermatology Centre, The University of Manchester, Salford NHS Foundation Trust, Manchester M6 8HD, UK.
Br J Dermatol. 2012 Mar;166(3):666-370. doi: 10.1111/j.1365-2133.2011.10692.x. Epub 2012 Jan 9.
Cosmetic surgical procedures, including hair transplantation and face-lift surgery, are becoming increasingly popular. However, there is very little information regarding the associated development of dermatological conditions following these procedures. Lichen planopilaris (LPP) is an uncommon inflammatory hair disorder of unknown aetiology that results in permanent alopecia and replacement of hair follicles with scar-like fibrous tissue. Frontal fibrosing alopecia (FFA), a variant of LPP, involves the frontal hairline and shares similar histological findings with those of LPP. We report 10 patients who developed LPP/FFA following cosmetic scalp surgery. Seven patients developed LPP following hair transplantation, and three patients developed FFA following face-lift surgery. In all cases there was no previous history of LPP or FFA. There is currently a lack of evidence to link the procedures of hair transplantation and cosmetic face-lift surgery to LPP and FFA, respectively. This is the first case series to describe this connection and to postulate the possible pathological processes underlying the clinical observation. Explanations include Koebner phenomenon induced by surgical trauma, an autoimmune process targeting an (as yet, unknown) hair follicle antigen liberated during surgery or perhaps a postsurgery proinflammatory milieu inducing hair follicle immune privilege collapse and follicular damage in susceptible individuals.
美容外科手术,包括毛发移植和面部提升术,越来越受欢迎。然而,关于这些手术后相关皮肤疾病的发展,信息却很少。瘢痕性类天疱疮(LPP)是一种病因不明的罕见炎症性毛发疾病,导致永久性脱发,毛囊被瘢痕样纤维组织取代。额部纤维性脱发(FFA)是 LPP 的一种变体,涉及额部发际线,与 LPP 的组织学发现相似。我们报告了 10 例美容头皮手术后发生 LPP/FFA 的患者。7 例患者在毛发移植后发生 LPP,3 例患者在面部提升手术后发生 FFA。在所有病例中,均无 LPP 或 FFA 的既往病史。目前尚无证据表明毛发移植和美容面部提升术分别与 LPP 和 FFA 有关。这是首例描述这种联系并推测潜在临床观察背后的可能病理过程的病例系列。解释包括手术创伤引起的 Koebner 现象、手术过程中释放的针对(目前尚不清楚的)毛囊抗原的自身免疫过程,或者是手术后促炎环境导致毛囊免疫豁免崩溃和易感个体的毛囊损伤。