HIV/AIDS/STI and TB (HAST) Research Programme, Human Sciences Research Council, Pretoria, South Africa.
BMC Public Health. 2011 Oct 10;11:778. doi: 10.1186/1471-2458-11-778.
Despite the availability of a dual therapy treatment protocol and infant feeding guidelines designed to prevent mother to child transmission (PMTCT) of HIV, of the over 1 million babies born in South Africa each year, only 70% of those born to HIV positive mothers receive dual therapy. Similar to other resource-poor nations facing the integration of PMTCT into routine pregnancy and infant care, efforts in South Africa to scale up PMTCT and reduce transmission to < 5% have fallen far short of the United Nation's goal of 50% reductions in paediatric HIV by 80% coverage of mothers.
METHODS/DESIGN: This study proposes to evaluate the impact of combining two evidence-based interventions: a couple's risk reduction intervention with an evidence based medication adherence intervention to enhance male participation in combination with improving medication and PMTCT adherence in antenatal clinics to increase PMTCT overall reach and effectiveness. The study will use a group-randomized design, recruiting 240 couples from 12 clinics. Clinics will be randomly assigned to experimental and control conditions and effectiveness of the combined intervention to enhance PMTCT as well as reduce antenatal seroconversion by both individuals and clinics will be examined.
Shared intervention elements may decrease sexual risk and enhance PMTCT uptake, e.g., increased male participation, enhanced communication, HIV counselling and testing, adherence, serostatus disclosure, suggest that a combined sexual risk reduction and adherence intervention plus PMTCT can increase male participation, increase couples' communication and encourage adherence to the PMTCT process. The findings will impact public health and will enable the health ministry to formulate policy related to male involvement in PMTCT, which will result in PMTCT.
PACTR201109000318329.
尽管有双疗法治疗方案和婴儿喂养指南可用于预防母婴传播艾滋病毒（PMTCT），但在南非每年出生的超过 100 万婴儿中，只有 70%的 HIV 阳性母亲所生婴儿接受了双疗法。与其他面临将 PMTCT 纳入常规妊娠和婴儿护理的资源匮乏国家类似，南非在扩大 PMTCT 和将传播率降低到 <5%方面的努力远远低于联合国将儿童艾滋病毒减少 50%的目标，这一目标需要实现 80%的母亲覆盖率。
方法/设计：本研究旨在评估结合两项基于证据的干预措施的效果：一对夫妇的风险降低干预措施和一项基于证据的药物依从性干预措施，以增强男性参与，同时改善产前诊所的药物和 PMTCT 依从性，从而提高 PMTCT 的总体覆盖率和效果。该研究将采用群组随机设计，从 12 个诊所招募 240 对夫妇。诊所将被随机分配到实验组和对照组，并将检验联合干预措施增强 PMTCT 以及降低个体和诊所产前血清转换的效果。
共享干预措施的要素可能会降低性风险并增强 PMTCT 的接受度，例如增加男性参与度、增强沟通、艾滋病毒咨询和检测、依从性、血清状态披露，这表明，将性风险降低和依从性干预措施与 PMTCT 相结合，可以增加男性参与度，增强夫妇之间的沟通，并鼓励他们坚持 PMTCT 过程。研究结果将对公共卫生产生影响，并使卫生部能够制定与男性参与 PMTCT 相关的政策，从而实现 PMTCT。
PACTR201109000318329。
