Nakamura K, Yamasaki M, Ohta H, Sasaki N, Murakami M, Bandula Kumara W R, Takiguchi M
Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Hokkaido 060-0818, Japan.
J Small Anim Pract. 2011 Nov;52(11):595-8. doi: 10.1111/j.1748-5827.2011.01127.x. Epub 2011 Oct 10.
To determine the effect of sildenafil for dogs with Eisenmeger's syndrome and secondary erythrocytosis.
This is a prospective, single arm, open-label study. Five clinical dogs with Eisenmeger's syndrome and secondary erythrocytosis were included. New York Heart Association functional class, packed cell volume, pulmonary artery acceleration time to ejection time ratio and serum erythropoietin concentration were evaluated before and after sildenafil therapy (0·5 mg/kg, twice a day).
New York Heart Association functional class was significantly improved after one (median 2; range 1 to 2, P=0·031) and three months (median 2; range 1 to 2, P=0·031) of sildenafil therapy, compared with the baseline (median 3, range 2 to 3). Packed cell volume was significantly decreased after three months (median 59%; range 56 to 63, P=0·031) of therapy, compared with the baseline (median 71%; range 58 to 74). Acceleration time to ejection time ratio had increased and serum erythropoietin concentration had decreased particularly after 1 month of therapy, but there was no statistical significance.
Sildenafil improved the clinical signs and secondary erythrocytosis in dogs with Eisenmeger's syndrome. Sildenafil therapy could be a useful treatment for dogs with Eisenmeger's syndrome.
确定西地那非对患有艾森曼格综合征和继发性红细胞增多症的犬的疗效。
这是一项前瞻性、单臂、开放标签研究。纳入了5只患有艾森曼格综合征和继发性红细胞增多症的临床犬。在西地那非治疗前后（0.5mg/kg，每日两次）评估纽约心脏协会心功能分级、红细胞压积、肺动脉加速时间与射血时间比值以及血清促红细胞生成素浓度。
与基线（中位数3，范围2至3）相比，西地那非治疗1个月（中位数2；范围1至2，P = 0.031）和3个月（中位数2；范围1至2，P = 0.031）后，纽约心脏协会心功能分级显著改善。治疗3个月后，与基线（中位数71%；范围58至74）相比，红细胞压积显著降低（中位数59%；范围56至63，P = 0.031）。特别是在治疗1个月后，加速时间与射血时间比值增加，血清促红细胞生成素浓度降低，但无统计学意义。
西地那非改善了患有艾森曼格综合征犬的临床症状和继发性红细胞增多症。西地那非治疗可能是患有艾森曼格综合征犬的一种有效治疗方法。
