Howard Hughes Medical Institute, New York, NY 10032, USA.
Annu Rev Cell Dev Biol. 2011;27:681-96. doi: 10.1146/annurev-cellbio-092910-154226.
The generation of individual neuron types in the nervous system is a multistep process whose endpoint is the expression of neuron type-specific batteries of terminal differentiation genes that determine the functional properties of a neuron. This review focuses on the regulatory mechanisms that are involved in controlling the terminally differentiated state of a neuron. I review several case studies from invertebrate and vertebrate nervous systems that reveal that many terminal differentiation features of a neuron are coregulated via terminal selector transcription factors that initiate and maintain terminal differentiation programs.
神经系统中单个神经元类型的产生是一个多步骤的过程，其终点是神经元类型特异性终端分化基因的表达，这些基因决定了神经元的功能特性。本文综述了参与控制神经元终末分化状态的调控机制。我回顾了来自无脊椎动物和脊椎动物神经系统的几个案例研究，这些研究表明，神经元的许多终末分化特征是通过起始和维持终末分化程序的终末选择转录因子共同调控的。
