来自内生漆斑菌属真菌的全取代不饱和内酯

Fully substituted unsaturated lactones from endophytic Myrothecium sp.

作者信息

Xu Hao, Jiang Nan, Guo Ye, Jiao Rui-Hua, Cui Jiang-Tao, Song Yong-Chun, Tan Ren-Xiang

机构信息

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, Nanjing University, Nanjing, 210093, China.

出版信息

J Asian Nat Prod Res. 2011 Oct;13(11):1003-7. doi: 10.1080/10286020.2011.605356. Epub 2011 Oct 10.

DOI:10.1080/10286020.2011.605356

PMID:21985747

Abstract

Two new α,β-unsaturated γ-lactones, myrolactones A (1) and B (2), were characterized from the culture broth of the Myrothecium sp. IFB-E106 isolated from the roots of Vatica mangachapoi Blauco. The absolute configuration was determined by the computational electronic circular dichroism approach. Myolactone B showed neuraminidase inhibitory activity with the IC(50) value of 13.95 μM.

摘要

从青梅（Vatica mangachapoi Blauco）根部分离得到的炭角菌属（Myrothecium sp.）IFB-E106的培养液中鉴定出两种新的α,β-不饱和γ-内酯，即肉芝内酯A（1）和B（2）。通过计算电子圆二色光谱方法确定了其绝对构型。肉芝内酯B表现出神经氨酸酶抑制活性，IC（50）值为13.95 μM。