来自印度楝内生真菌拟茎点霉属的十元内酯

Ten-membered lactones from Phomopsis sp., an endophytic fungus of Azadirachta indica.

作者信息

Wu Shao-Hua, Chen You-Wei, Shao Shi-Cheng, Wang Li-Dong, Li Zhi-Ying, Yang Li-Yuan, Li Shao-Lan, Huang Rong

机构信息

Yunnan Institute of Microbiology and Laboratory Center, Yunnan University, Kunming 650091, People's Republic of China.

出版信息

J Nat Prod. 2008 Apr;71(4):731-4. doi: 10.1021/np070624j. Epub 2008 Mar 13.

DOI:10.1021/np070624j

PMID:18336005

Abstract

Four new 10-membered lactones ( 1- 4) and one known one ( 5) were isolated from the broth extract of an endophytic fungus, Phomopsis sp., obtained from the stem of Azadirachta indica. Their structures were assigned by analysis of spectroscopic data, and the structures of 1 and 4 were also confirmed by X-ray analysis. Compounds 1- 5 were tested for antifungal activity against several plant pathogens. Compound 4 demonstrated antifungal activity in the MIC value range 31.25-500 microg/mL.

摘要

从印楝茎中分离得到的内生真菌拟茎点霉（Phomopsis sp.）的发酵液提取物中，分离出了4个新的10元内酯（1 - 4）和1个已知化合物（5）。通过光谱数据分析确定了它们的结构，1和4的结构还通过X射线分析得到了证实。对化合物1 - 5进行了针对几种植物病原体的抗真菌活性测试。化合物4在31.25 - 500微克/毫升的最低抑菌浓度（MIC）值范围内表现出抗真菌活性。