化疗后β-人绒毛膜促性腺激素阴性绒癌自发性子宫穿孔。
Spontaneous uterine perforation of choriocarcinoma with negative beta-human chorionic gonadotropin after chemotherapy.
机构信息
Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, PR China.
出版信息
Med Princ Pract. 2011;20(6):570-3. doi: 10.1159/000330028. Epub 2011 Oct 4.
OBJECTIVE
To report an extremely rare case of spontaneous uterine perforation of choriocarcinoma with negative beta-human chorionic gonadotropin (β-hCG) post-chemotherapy.
CLINICAL PRESENTATION AND INTERVENTION
We present a 35-year-old choriocarcinoma patient whose serial serum β-hCG levels following a fifth course of chemotherapy had been within the normal range, but who developed spontaneous uterine perforation with intra-abdominal hemorrhage after eight courses of combined chemotherapy. The patient then underwent an emergency hysterectomy and survived.
CONCLUSION
Patients with persistent focus of disease in the uterus might experience uterine perforation even after adequate chemotherapy, and therefore, the follow-up for patients after chemotherapy is very important.
目的
报告一例极其罕见的化疗后β-人绒毛膜促性腺激素（β-hCG）阴性绒毛膜癌自发性子宫穿孔病例。
临床表现及干预
我们报告了一例 35 岁的绒毛膜癌患者，在第五轮化疗后，其血清β-hCG 水平连续处于正常范围，但在第八轮联合化疗后发生自发性子宫穿孔伴腹腔内出血。患者随后行急症子宫切除术并存活。
结论
即使经过充分的化疗，持续性子宫病灶的患者仍可能发生子宫穿孔，因此，化疗后患者的随访非常重要。
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