吸烟在胰腺炎发病机制中的新作用。
The emerging role of smoking in the development of pancreatitis.
机构信息
Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, Conn., USA.
出版信息
Pancreatology. 2011;11(5):469-74. doi: 10.1159/000332196. Epub 2011 Oct 5.
Abstract
BACKGROUND/AIMS: Cigarette smoking has been linked to many diseases, including pancreatic cancer and more recently, pancreatitis.
METHODS
Electronic searches of primarily PubMed from 1990 to August 2011 were conducted and only articles published in English were reviewed. Original articles and reviews were selected based on screening of article abstracts and their relevance to tobacco smoking, its components, nicotine and its metabolites, and their effects particularly on the pancreas.
RESULTS
Smoking may affect the risk of developing chronic pancreatitis or its progression. Smoking may also affect the risk for developing acute pancreatitis. Its effects in pancreatitis appear to be dose dependent and its effects may be alcohol independent but synergize with alcohol.
CONCLUSION
Specific constituents of cigarette smoke, including nicotine and its metabolites, could mediate effects on the pancreas.
摘要
背景/目的：吸烟与许多疾病有关，包括胰腺癌，以及最近的胰腺炎。
方法
主要对 1990 年至 2011 年 8 月期间的 PubMed 进行电子检索，仅审查以英文发表的文章。根据文章摘要的筛选及其与吸烟、其成分、尼古丁及其代谢物及其对胰腺的影响，特别是对胰腺的影响，选择原始文章和综述。
结果
吸烟可能会影响慢性胰腺炎的发展或其进展的风险。吸烟也可能会影响急性胰腺炎的发病风险。其在胰腺炎中的作用似乎是剂量依赖性的，其作用可能与酒精无关，但与酒精有协同作用。
结论
香烟烟雾的特定成分，包括尼古丁及其代谢物，可能会对胰腺产生影响。
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