Nakanaga Kazue, Hoshino Yoshihiko, Hattori Yoko, Yamamoto Atsushi, Wada Shinpei, Hatai Kishio, Makino Masahiko, Ishii Norihisa
Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4–2–1 Aoba, Higashimurayama, Tokyo 189–0002, Japan.
J Vet Med Sci. 2012 Feb;74(2):275-8. doi: 10.1292/jvms.11-0226. Epub 2011 Oct 11.
Mycobacteria isolated from epizootics of farmed fishes in western Japan were examined for the first time using multigenotypic analysis. By analysis of the sequences of the internal transcribed spacer between the 16S and 23S rRNA genes (ITS) region and the partial 16S rRNA, hsp65 and rpoB genes, M. pseudoshottsii was identified as the causative agent in these infections. Prior to this study, only M. marinum has been known as the causative agent of lethal mycobacterial disease in marine fishes in Japan.
首次使用多基因型分析方法对从日本西部养殖鱼类的动物流行病中分离出的分枝杆菌进行了检测。通过分析16S和23S rRNA基因之间的内部转录间隔区（ITS）以及部分16S rRNA、hsp65和rpoB基因的序列，鉴定出伪肖茨分枝杆菌是这些感染的病原体。在本研究之前，在日本，仅海鱼分枝杆菌被认为是海洋鱼类致死性分枝杆菌病的病原体。
