Institute of Oncology, Ziv Medical Center, Faculty of Medicine, Zefat, Israel.
Curr Opin Clin Nutr Metab Care. 2011 Nov;14(6):588-97. doi: 10.1097/MCO.0b013e32834bfe94.
Several nutritional compounds are the focus of public attention because of their potential beneficial health effects. Turmeric is a spice that comes from the root Curcuma longa. Extensive research over the past half century and especially in recent years has revealed important functions of curcumin and a timely review of clinical state-of-the-art using curcumin.
In-vitro and in-vivo research has shown various activities, such as anti-inflammatory, antiviral, antifungal, cytokines release, antioxidant, immunomodulatory, enhancing of the apoptotic process, and antiangiogenic properties. Curcumin also have been shown to be a mediator of chemo-resistance and radio-resistance.
Various in-vitro and in-vivo and scarce number of clinical studies on curcumin were identified. The various effects and properties of curcumin are summarized in this review, including preclinical and especially clinical studies. This review concentrates on recent knowledge and research with curcumin clinical applications, and clinical studies, focusing on studies published between 2008 and 2011 demonstrating the gap between preclinical and clinical research.
综述目的：有几种营养化合物因其潜在的有益健康的影响而受到公众关注。姜黄是一种来自姜黄根的香料。过去半个世纪，特别是近年来的广泛研究揭示了姜黄素的重要功能，及时回顾了使用姜黄素的临床最新进展。
最新发现：体外和体内研究表明，姜黄素具有多种活性，如抗炎、抗病毒、抗真菌、细胞因子释放、抗氧化、免疫调节、促进细胞凋亡和抗血管生成特性。姜黄素还被证明是化疗耐药性和放射耐药性的介质。
总结：本综述集中于姜黄素临床应用和临床研究的最新知识和研究，重点关注 2008 年至 2011 年发表的研究，这些研究表明了临床前和临床研究之间的差距。
