Tayyem Reema F, Heath Dennis D, Al-Delaimy Wael K, Rock Cheryl L
Clinical Nutrition and Dietetics Department, Allied Health Sciences Faculty, The Hashemite University, Jordan.
Nutr Cancer. 2006;55(2):126-31. doi: 10.1207/s15327914nc5502_2.
Curcumin, derived from the rhizome curcuma longa, is one of the primary ingredients in turmeric and curry powders that are used as spices in Middle Eastern and Asian countries, especially on the Indian subcontinent. More recently, laboratory studies have demonstrated that dietary curcumin exhibits various biological activities and significantly inhibits colon tumorigenesis and tumor size in animals. Curcumin displays both anti-inflammatory and antioxidant properties, giving it the potential to be considered in the development of cancer preventive strategies and applications in clinical research. Experimental studies have shown the biological activities of the compound, but much more information on pharmacokinetics, bioavailability, and food content are needed. Whether the amount of curcumin in turmeric and curry powders is sufficient to suggest effects on biological activities and cancer risk is unknown. To determine and compare the quantitative amounts of curcumin that are present in several brands of turmeric and curry powders, a high performance liquid chromatography technique was used to analyze 28 spice products described as turmeric or curry powders and two negative controls. Pure turmeric powder had the highest curcumin concentration, averaging 3.14% by weight. The curry powder samples, with one exception, had relatively small amounts of curcumin present, and the variability in content was great. The curcumin content of these seasoning products that are consumed as a component of the diet should be considered in evaluating baseline tissue concentration and response to curcumin supplementation, which is under study in chemoprevention trials.
姜黄素源自姜黄根茎,是姜黄和咖喱粉中的主要成分之一,中东和亚洲国家,尤其是印度次大陆,将其用作香料。最近,实验室研究表明,膳食姜黄素具有多种生物活性,并能显著抑制动物的结肠肿瘤发生和肿瘤大小。姜黄素具有抗炎和抗氧化特性,使其有潜力被纳入癌症预防策略的开发以及临床研究应用中。实验研究已经表明了该化合物的生物活性,但还需要更多关于药代动力学、生物利用度和食物含量的信息。姜黄和咖喱粉中的姜黄素含量是否足以显示对生物活性和癌症风险的影响尚不清楚。为了测定和比较几个品牌的姜黄和咖喱粉中姜黄素的定量含量,采用高效液相色谱技术分析了28种被描述为姜黄或咖喱粉的香料产品以及两个阴性对照。纯姜黄粉的姜黄素浓度最高,平均重量为3.14%。除了一个例外,咖喱粉样品中的姜黄素含量相对较少,且含量差异很大。在评估基线组织浓度以及对姜黄素补充剂的反应时,应考虑这些作为饮食成分食用的调味产品中的姜黄素含量,目前姜黄素补充剂正在化学预防试验中进行研究。