Department of Nutrition, School of Medicine, Mashad University of Medical Sciences, Mashad, Iran.
J Endocrinol Invest. 2012 Sep;35(8):766-71. doi: 10.3275/8015. Epub 2011 Oct 6.
Although Muslim patients with Type 2 diabetes may be exempt from fasting during Ramadan for medical reasons, a high proportion of them fast.
To investigate the association between Ramadan fasting and glycemic control in patients with Type 2 diabetes.
A prospective cohort clinical trial was designed. Eighty-eight patients with Type 2 diabetes (45 male, 43 female, age 51±10 yr) who opted to fast for at least 10 days during the month of Ramadan were recruited. Fasting blood samples were taken at the beginning and end of Ramadan, and 1 month after Ramadan, to assess fasting blood glucose (FBG), fasting insulin, full blood count, glycated hemoglobin (HbA(1c)) and fasting lipid profile. Insulin resistance was estimated using the homeostatic model assessment. Anthropometrics and blood pressure were also measured.
There was a significant deterioration in FBG and HbA(1c) (p=0.002 and p≤0.001, respectively) and significant improvements in HDL and LDL cholesterol and body mass index after Ramadan (p<0.001). Interestingly, HbA(1c) showed a reduction 1 month after Ramadan (9.4±2% at the end of Ramadan vs 8.4±2.5% 1 month after Ramadan; p<0.001).
Results from this study showed that fasting during Ramadan deteriorated the glycemic control in Type 2 diabetes patients. This was more evident in patients using oral hypoglycemic medication than diet- controlled patients. However, Ramadan fasting had small positive effects on lipid profile and body weight.
尽管出于医疗原因，穆斯林 2 型糖尿病患者可能被豁免在斋月期间禁食，但仍有很大一部分人会选择斋戒。
调查 2 型糖尿病患者在斋月期间禁食与血糖控制之间的关系。
设计了一项前瞻性队列临床试验。招募了 88 名选择在斋月期间至少禁食 10 天的 2 型糖尿病患者（男性 45 名，女性 43 名，年龄 51±10 岁）。在斋月开始和结束时以及斋月结束后 1 个月采集空腹血样，以评估空腹血糖（FBG）、空腹胰岛素、全血细胞计数、糖化血红蛋白（HbA1c）和空腹血脂谱。使用稳态模型评估法估计胰岛素抵抗。还测量了人体测量学和血压。
FBG 和 HbA1c 显著恶化（p=0.002 和 p≤0.001），HDL 和 LDL 胆固醇以及体重指数在斋月后显著改善（p<0.001）。有趣的是，HbA1c 在斋月结束后 1 个月（9.4±2% vs 8.4±2.5%；p<0.001）有所下降。
本研究结果表明，斋月禁食会恶化 2 型糖尿病患者的血糖控制。这在使用口服降糖药的患者中比饮食控制的患者更为明显。然而，斋月禁食对血脂谱和体重有较小的积极影响。
