斋月禁食对2型糖尿病患者胎球蛋白-A水平的影响。
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus.
作者信息
Harbuwono Dante S, Sazli Brama I, Kurniawan Farid, Darmowidjojo Budiman, Koesnoe Sukamto, Tahapary Dicky L
机构信息
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia.
Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Jakarta, Indonesia.
出版信息
Heliyon. 2021 May 15;7(5):e06773. doi: 10.1016/j.heliyon.2021.e06773. eCollection 2021 May.
BACKGROUND/AIMS: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM).
MATERIALS AND METHODS
This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters.
RESULTS
Ramadan fasting reduced Fetuin-A levels [median (minimum-maximum), 5.35 (2.91-7.81) vs. 3.22 (2.35-5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan.
CONCLUSION
Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan.
背景/目的：斋月禁食会导致生活方式改变，引发影响葡萄糖代谢和胰岛素敏感性的生化变化。本研究旨在评估斋月禁食对2型糖尿病（T2DM）患者血糖控制以及胎球蛋白A（一种影响胰岛素抵抗的糖蛋白）的影响。
材料与方法
这是一项对印度尼西亚雅加达一家医院内科综合门诊的37例T2DM患者进行的前瞻性研究。在三个时间点测量受试者的人体测量数据以及血红蛋白A1c（HbA1c）、空腹血糖（FBG）和胎球蛋白A水平：斋月禁食前、期间和之后。进行双变量分析以观察斋月禁食对这些参数的影响。
结果
与斋月前相比，斋月结束四周后，斋月禁食降低了胎球蛋白A水平[中位数（最小值 - 最大值），5.35（2.91 - 7.81）对3.22（2.35 - 5.60）mg/dl；p = 0.039]。斋月禁食两周后，我们发现体重、BMI、FBG和HbA1c水平显著降低，斋月后又反弹至基线水平。
结论
斋月禁食与斋月后胎球蛋白A水平显著降低有关。
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