Wei Yuejiao, Liu Daicheng
Key Laboratory of Animal Resistance, College of Life Science, Shandong Normal University, Jinan, China.
Toxicol Ind Health. 2012 Aug;28(7):579-82. doi: 10.1177/0748233711416950. Epub 2011 Oct 10.
In September 2008, in China, tens of thousands of children were hospitalized, several even died, as a result of infant-formula milk adulterated with a synthetic chemical compound, melamine, and in the next few months, this crisis became the focus of attention worldwide. Although there are a number of articles about melamine toxicity on different species of animals, the long-term effect of melamine on humans is still unknown. Besides, several recent in vitro studies indicated that melamine can damage cells of other parts of the body, including the central nervous system, breaking the previous view that melamine toxicity is limited to the urinary system. Hence, we strongly recommend a long-term follow-up for the overall health status of the victims, not confined to kidneys, to minimize the potential toxic effects in their later life; and research to study the specific mechanism of melamine should be encouraged.
2008年9月，在中国，数以万计的儿童因食用掺有合成化合物三聚氰胺的婴儿配方奶粉而住院，有几名儿童甚至死亡，在接下来的几个月里，这场危机成为全球关注的焦点。虽然有许多关于三聚氰胺对不同动物物种毒性的文章，但三聚氰胺对人类的长期影响仍然未知。此外，最近的几项体外研究表明，三聚氰胺会损害身体其他部位的细胞，包括中枢神经系统，这打破了之前三聚氰胺毒性仅限于泌尿系统的观点。因此，我们强烈建议对受害者的整体健康状况进行长期跟踪，而不仅限于肾脏，以尽量减少他们晚年可能出现的毒性影响；并且应鼓励开展研究以探究三聚氰胺的具体作用机制。
