Makni Mohamed, Chtourou Yassine, Barkallah Mohamed, Fetoui Hamadi
Animal Physiology Laboratory, University of Sfax, Sfax, Tunisia.
Toxicol Ind Health. 2012 Aug;28(7):655-62. doi: 10.1177/0748233711420472. Epub 2011 Oct 10.
This study investigated the protective effects of vanillin against acute brain damage induced by carbon tetrachloride (CCl₄) in rats. The study was performed on 32 male rats divided into four groups: a control group, vanillin group ([Va] 150 mg/kg/day, intraperitoneally [i.p.]) and CCl₄ toxication groups received a single injection of CCl₄ (1 ml/kg, i.p.; CCl₄ and Va + CCl₄ groups). The degree of protection in brain tissue was evaluated by the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase, glutathione transferase, glutathione peroxidase and nitric oxide (NO). Vanillin showed a significant brain-protective effect by decreasing the level of lipid peroxidation and NO₂ and elevated the activities of antioxidative enzymes and level of GSH. Consequently vanillin blocked oxidative brain damage induced by CCl₄ in rats.
本研究调查了香草醛对四氯化碳（CCl₄）诱导的大鼠急性脑损伤的保护作用。该研究对32只雄性大鼠进行，分为四组：对照组、香草醛组（[Va] 150毫克/千克/天，腹腔注射[i.p.]）以及CCl₄中毒组（接受单次CCl₄注射[1毫升/千克，腹腔注射；CCl₄组和Va + CCl₄组]）。通过丙二醛（MDA）、谷胱甘肽（GSH）、超氧化物歧化酶、谷胱甘肽转移酶、谷胱甘肽过氧化物酶和一氧化氮（NO）的水平评估脑组织的保护程度。香草醛通过降低脂质过氧化水平和NO₂表现出显著的脑保护作用，并提高了抗氧化酶的活性和GSH水平。因此，香草醛阻止了CCl₄诱导的大鼠脑氧化损伤。
