Department of Radiation Biology, Institute for Cancer Research, the Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310, Oslo, Norway.
Photochem Photobiol Sci. 2012 Jan;11(1):191-8. doi: 10.1039/c1pp05215b. Epub 2011 Oct 11.
Latitudinal dependencies of UVA and UVB were studied together with relevant epidemiological data for squamous cell carcinoma (SCC) and cutaneous malignant melanoma (CMM) in Norway and Sweden. Our data support the hypothesis that solar UVA radiation may play a role for CMM induction. The etiologies of SCC and CMM are different according to a latitudinal dependency and differences in age curves. Sun exposure patterns, age-related decay rates of repair of UV damage and sex hormones may play different roles for the two skin cancers. Also, UVB induction of vitamin D may be involved. CMM incidence rates among young people have decreased or been constant since about 1990 in Norway and Sweden. All reasons for UVA contributing to CMM will be discussed.
本研究结合挪威和瑞典的鳞状细胞癌 (SCC) 和皮肤恶性黑色素瘤 (CMM) 的相关流行病学数据，共同探讨了 UVA 和 UVB 的纬度依赖性。我们的数据支持了这样一种假设，即太阳 UVA 辐射可能在 CMM 的诱导中发挥作用。SCC 和 CMM 的病因根据纬度依赖性和年龄曲线的差异而有所不同。阳光暴露模式、与年龄相关的紫外线损伤修复能力下降以及性激素，可能在这两种皮肤癌中发挥不同的作用。此外，维生素 D 的 UVB 诱导作用也可能涉及其中。自 1990 年以来，挪威和瑞典年轻人的 CMM 发病率已经下降或保持不变。我们将讨论所有与 UVA 有关的导致 CMM 的因素。
