Department of Radiation Biology, Institute for Cancer Research, the Norwegian Radium Hospital, Montebello 0310 Oslo Institute of Physics, University of Oslo, Blindern 0316 Oslo, Norway.
J Eur Acad Dermatol Venereol. 2012 Jul;26(7):821-7. doi: 10.1111/j.1468-3083.2011.04162.x. Epub 2011 Jun 28.
Cutaneous malignant melanoma (CMM) incidence continues to increase in many parts of the world. Solar ultraviolet (UV) radiation is the main environmental risk factor for CMM. Different body locations are subjected to different doses and exposure patterns of solar UV. Time and latitudinal trends of CMMs on shielded and exposed skin give valuable information about the aetiology of these cancers. In this study, we have compared the time and latitudinal trends of CMM incidence on skin areas which are chronically (head and neck) and rarely (foot) exposed to UV radiation, to gain more information about the relationship between sun doses, exposure patterns and melanomagenesis.
We have analysed epidemiological data from the Cancer Registry of Norway, for foot and head and neck CMM for two time periods: 1966-1986 and 1987-2007.
Cutaneous malignant melanoma incidence rate on head and neck has increased with time, while incidence rates of foot CMM have remained almost constant with time in Norway. There is a large north-south gradient in incidence rates of CMM on head and neck in Norway, while there is almost no north-south gradient for CMM incidence on foot.
Comparisons of time trends and latitudinal trends of the incidence rates of CMM on head/neck and on foot indicate that solar radiation plays a role in the induction of the former CMM but probably not for the latter.
在世界许多地区，皮肤恶性黑素瘤（CMM）的发病率持续上升。太阳紫外线（UV）辐射是 CMM 的主要环境危险因素。不同的身体部位受到不同剂量和太阳 UV 暴露模式的影响。有遮蔽和无遮蔽皮肤 CMM 的时间和纬度趋势为这些癌症的病因学提供了有价值的信息。在这项研究中，我们比较了长期（头颈部）和很少暴露（足部）于 UV 辐射的皮肤区域的 CMM 发病率的时间和纬度趋势，以获得更多关于太阳剂量、暴露模式和黑素瘤发生之间关系的信息。
我们分析了挪威癌症登记处的流行病学数据，包括 1966-1986 年和 1987-2007 年两个时期足部和头颈部 CMM 的发病情况。
在挪威，头颈部皮肤恶性黑素瘤的发病率随时间增加，而足部 CMM 的发病率随时间几乎不变。在挪威，头颈部 CMM 的发病率存在很大的南北梯度，而足部 CMM 的发病率几乎没有南北梯度。
对头/颈和足部 CMM 发病率的时间趋势和纬度趋势的比较表明，太阳辐射在诱导前者 CMM 中起作用，但可能对后者不起作用。
