Miao Maohua, Yuan Wei, He Yonghua, Zhou Zhijun, Wang Jintao, Gao Ersheng, Li Guohong, Li De-Kun
Division of Research, Kaiser Foundation Research Institute, Kaiser Permanente, Oakland, California 94612, USA.
Birth Defects Res A Clin Mol Teratol. 2011 Oct;91(10):867-72. doi: 10.1002/bdra.22845. Epub 2011 Aug 26.
Bisphenol-A (BPA) is an endocrine disruptor with widespread human exposure. The effect of in utero BPA exposure on human offspring remains largely unknown.
Anogenital distance (AGD) of sons of workers who did or did not have occupational BPA exposure during pregnancy were compared in an occupational cohort study. Parental BPA exposure level during the index pregnancy was estimated through a job-exposure matrix based on personal air sampling measurement. Maternal exposure was considered direct in utero exposure to the fetus, whereas paternal exposure was considered indirect in utero exposure.
A total of 153 boys were included in the final analysis, among them 56 with parental occupational exposure during pregnancy and 97 without. After controlling for the boys' ages and weights using linear regression, parental occupational exposure to BPA during pregnancy was associated with shortened AGD in male offspring. The association was stronger for maternal exposure (p < 0.01). There was also a dose-response relationship with increased BPA exposure levels in pregnancy associated with greater magnitude of shortened AGD in male offspring, with a statistically significant trend for the association (p = 0.008).
Our findings provide the first epidemiologic evidence that in utero BPA exposure may adversely affect male genital development.
双酚A（BPA）是一种内分泌干扰物，人类广泛接触。子宫内接触BPA对人类后代的影响仍 largely未知。
在一项职业队列研究中，比较了孕期有或无职业性BPA接触的工人儿子的肛门生殖器距离（AGD）。通过基于个人空气采样测量的工作接触矩阵估计指数孕期父母的BPA接触水平。母亲接触被认为是对胎儿的直接子宫内接触，而父亲接触被认为是间接子宫内接触。
共有153名男孩纳入最终分析，其中56名在孕期父母有职业接触，97名没有。使用线性回归控制男孩的年龄和体重后，孕期父母职业性接触BPA与男性后代AGD缩短有关。母亲接触的关联更强（p < 0.01）。孕期BPA接触水平增加与男性后代AGD缩短幅度更大之间也存在剂量反应关系，该关联有统计学显著趋势（p = 0.008）。
我们的研究结果提供了首个流行病学证据，表明子宫内接触BPA可能对男性生殖器发育产生不利影响。
