Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94107, USA.
J Magn Reson Imaging. 2012 Feb;35(2):370-8. doi: 10.1002/jmri.22834. Epub 2011 Oct 10.
To examine the changes in knee cartilage T2 values over 24 months in subjects with and without risk factors for knee osteoarthritis (OA) and their association with focal knee lesions at baseline.
Forty-one subjects without and 101 subjects with OA risk factors (such as history of knee injury or surgery) were selected from the Osteoarthritis Initiative database (age: 45-55 years, no radiographic OA in the right knee). Baseline magnetic resonance imaging (MRI) of the right knee were assessed for prevalence and grade of focal knee lesions. Right knee cartilage T2 measurements were performed in five compartments (patella, medial/lateral femur/tibia) at baseline and at 24-month follow-up.
Compared to subjects without OA risk factors, those with OA risk factors showed no significant differences in baseline prevalence and grade of focal knee lesions (P > .05), but had significantly higher T2 values in the medial femur compartment at both timepoints (P < 0.05). T2 values averaged over all five compartments increased significantly over 24 months in both groups, but differences in T2 increase between the groups were not significant. Subjects with cartilage lesions showed significantly higher T2 values compared to subjects without cartilage lesions at both timepoints, but no accelerated T2 increase over 24 months (P > 0.05).
Cartilage T2 values significantly increased over 24 months in subjects with and without OA risk factors, but neither the presence of OA risk factors nor the presence of cartilage lesions at baseline were associated with these T2 increases.
观察无膝关节骨关节炎（OA）危险因素和有膝关节 OA 危险因素的受试者膝关节软骨 T2 值在 24 个月内的变化，并探讨其与基线时膝关节局灶性病变的关系。
从骨关节炎倡议数据库中选择 41 名无膝关节 OA 危险因素（如膝关节损伤或手术史）和 101 名有膝关节 OA 危险因素的受试者（年龄：45-55 岁，右膝关节无放射学 OA）。对右膝关节的基线磁共振成像（MRI）进行评估，以了解局灶性膝关节病变的患病率和分级。在基线和 24 个月随访时，对右膝关节 5 个间室（髌骨、股骨内/外侧、胫骨）的软骨 T2 值进行测量。
与无膝关节 OA 危险因素的受试者相比，有膝关节 OA 危险因素的受试者基线时局灶性膝关节病变的患病率和分级无显著差异（P＞0.05），但在两个时间点的股骨内髁间室 T2 值均显著升高（P＜0.05）。两组的 T2 值在 24 个月内均显著升高，但两组间 T2 值的增加无显著差异。在两个时间点，有软骨病变的受试者的 T2 值均显著高于无软骨病变的受试者，但在 24 个月内 T2 值的增加无加速（P＞0.05）。
无论是否存在膝关节 OA 危险因素，受试者的膝关节软骨 T2 值在 24 个月内均显著增加，但膝关节 OA 危险因素的存在或基线时的软骨病变均与这些 T2 值的增加无关。
