一种通过Petasis方法在两步合成操作中合成喹喔啉文库的新途径。
A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations.
作者信息
Ayaz Muhammad, Dietrich Justin, Hulme Christopher
机构信息
College of Pharmacy, BIO5 Oro Valley, The University of Arizona, Tucson, AZ.
出版信息
Tetrahedron Lett. 2011 Sep 21;52(38):4821-4823. doi: 10.1016/j.tetlet.2011.06.115.
Abstract
This communication reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields.
摘要
本通讯报道了一种创新且简便的方法，通过两步合成制备喹喔啉。首先进行微波辅助的Petasis反应，然后通过酸介导使内部氨基亲核试剂脱保护、环脱水和氧化，以良好至优异的产率得到喹喔啉类化合物。
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