泊沙康唑治疗慢性难治性球孢子菌性脑膜炎。
Posaconazole for chronic refractory coccidioidal meningitis.
机构信息
Maternal Child and Adolescent Center for Infectious Diseases and Virology, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
出版信息
Clin Infect Dis. 2011 Dec;53(12):1252-4. doi: 10.1093/cid/cir734. Epub 2011 Oct 10.
Coccidioidal meningitis is a potentially lethal infection. Disease progression while taking fluconazole is a common complication and safe, effective, alternative treatments are limited. Posaconazole therapy resulted in symptomatic and laboratory improvement in 2 patients and clinical improvement in a third patient with chronic, previously unresponsive coccidioidal meningitis.
球孢子菌性脑膜炎是一种潜在致命的感染。在服用氟康唑时出现疾病进展是一种常见的并发症，而且安全有效的替代治疗方法有限。在 2 名患有慢性、先前对抗真菌药物无反应的球孢子菌性脑膜炎的患者中，泊沙康唑治疗使症状和实验室指标改善，在第 3 名患者中使临床症状改善。
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