Smart Ageing International Research Center, Institute of Development, Aging and Cancer, Department of Functional Brain Imaging, Faculty of Medicine, Tohoku University, Sendai, Japan.
Neuroimage. 2012 Feb 1;59(3):2899-907. doi: 10.1016/j.neuroimage.2011.09.064. Epub 2011 Oct 1.
During Stroop tasks, subjects experience cognitive interference when they resolve interferences such as identifying the ink color of a printed word while ignoring the word's identity. Stroop paradigms are commonly used as an index of attention deficits and a tool for investigating the functions of the frontal lobes and other associated structures. Despite these uses and the vast amount of attention given to Stroop paradigms, the regional gray matter volume/regional white matter volume (rGMV/rWMV) correlates of Stroop interference have not yet been identified at the whole brain level in normal adults. We examined this issue using voxel-based morphometry in right-handed healthy young adults. We found significant negative relationships between the Stroop interference rate and rGMV in the anterior cingulate cortex (ACC), right inferior frontal gyrus, and cerebellum. Furthermore, we found relationships between the Stroop interference rate and rWMV in bilateral anatomical clusters that extended around extensive WM regions in the dorsal part of the frontal lobe. These findings are the first to reveal rGMV/rWMV that underlie the performance of the Stroop task, a widely used psychological paradigm at the whole brain level. Of note, our findings support the notion that ACC contributes to Stroop performance and show the involvement of regions that have been implicated in response inhibition and attention.
在斯特鲁普任务中，当受试者在解决干扰时，例如忽略单词的身份而识别印刷单词的墨水颜色，他们会经历认知干扰。斯特鲁普范式通常被用作注意力缺陷的指标，也是研究额叶和其他相关结构功能的工具。尽管这些用途以及对斯特鲁普范式的大量关注，但在正常成年人的全脑水平上，尚未确定斯特鲁普干扰的区域灰质体积/区域白质体积（rGMV/rWMV）相关性。我们使用右利手健康年轻成年人的基于体素的形态测量学研究了这个问题。我们发现，在扣带前回、右额下回和小脑，斯特鲁普干扰率与 rGMV 之间存在显著的负相关关系。此外，我们还发现了斯特鲁普干扰率与双侧解剖簇之间的关系，这些簇在额叶背侧的广泛 WM 区域周围延伸。这些发现首次揭示了在全脑水平上，广泛使用的心理范式——斯特鲁普任务的 rGMV/rWMV 基础。值得注意的是，我们的发现支持了 ACC 对斯特鲁普表现有贡献的观点，并显示了与反应抑制和注意力相关的区域的参与。
