Hill N C, Selinger M, Ferguson J, López Bernal A, Mackenzie I Z
Nuffield Department of Obstetrics & Gynaecology, University of Oxford, John Radcliffe Hospital, Headington.
Br J Obstet Gynaecol. 1990 Jun;97(6):487-92. doi: 10.1111/j.1471-0528.1990.tb02517.x.
A double-blind placebo-controlled trial was performed in 20 primigravidae to assess the physiological and clinical effects of oral mifepristone on myometrial contractility and sensitivity in the second trimester. Ten women received 600 mg of oral mifepristone and 10 women a placebo 24 h before abortion was induced in both groups, with extra-amniotic PGE2 instillation. Intrauterine pressure recordings demonstrated increased spontaneous uterine activity and increased sensitivity to PGE2 and ergometrine, but no change in oxytocin sensitivity after mifepristone treatment. There were no significant differences in PGE or PGF metabolite concentrations in peripheral maternal plasma over the 24-h study period after treatment between the mifepristone and placebo groups. The mean induction abortion interval in the mifepristone group was 512 (SD 321) min compared with 1128 (SD 606) min in the placebo group (P less than or equal to 0.02). The mechanism whereby mifepristone provokes enhanced uterine contractility and sensitivity to prostaglandins, with a reduction in abortion times, does not appear to be through endogenous production of PGE or PGF.
对20名初产妇进行了一项双盲安慰剂对照试验，以评估口服米非司酮对孕中期子宫肌层收缩性和敏感性的生理及临床影响。两组均在羊膜外滴注前列腺素E2引产24小时前，10名妇女服用600毫克口服米非司酮，10名妇女服用安慰剂。子宫内压力记录显示，米非司酮治疗后子宫自发活动增加，对前列腺素E2和麦角新碱的敏感性增加，但对催产素的敏感性无变化。在治疗后的24小时研究期内，米非司酮组和安慰剂组母体外周血浆中前列腺素E或前列腺素F代谢物浓度无显著差异。米非司酮组的平均引产间隔为512（标准差321）分钟，而安慰剂组为1128（标准差606）分钟（P≤0.02）。米非司酮增强子宫收缩性和对前列腺素的敏感性并缩短流产时间的机制似乎不是通过内源性产生前列腺素E或前列腺素F。
