Shah Duru, Nagarajan Nagadeepti
Gynaecworld and Gynaecworld Assisted Fertility Unit Mumbai, Gynaecworld, Mumbai, India.
Indian J Endocrinol Metab. 2013 Jan;17(1):44-9. doi: 10.4103/2230-8210.107834.
Luteal phase insufficiency is one of the reasons for implantation failure and has been responsible for miscarriages and unsuccessful assisted reproduction. Luteal phase defect is seen in women with polycystic ovaries, thyroid and prolactin disorder. Low progesterone environment is created iatrogenically due to interventions in assisted reproduction. Use of gonadotrophin-releasing hormone analogs to prevent the LH surge and aspiration of granulosa cells during the oocyte retrieval may impair the ability of corpus luteum to produce progesterone. Treatment of the underlying disorder and use of progestational agents like progesterone/human chorionic gonadotrophin have been found to be effective in women with a history of recurrent miscarriage. There has been no proved beneficial effect of using additional agents like ascorbic acid, estrogen, prednisolone along with progesterone. Despite their widespread use, further studies are required to establish the optimal treatment. Literature review and analysis of published studies on luteal phase support.
黄体期缺陷是着床失败的原因之一，也是导致流产和辅助生殖失败的原因。多囊卵巢、甲状腺和催乳素紊乱的女性会出现黄体期缺陷。辅助生殖中的干预措施会医源性地造成低孕酮环境。使用促性腺激素释放激素类似物来防止促黄体生成素激增以及在取卵过程中抽吸颗粒细胞，可能会损害黄体产生孕酮的能力。对于有复发性流产史的女性，治疗潜在疾病并使用孕酮/人绒毛膜促性腺激素等孕激素已被证明是有效的。尚未证实与孕酮一起使用抗坏血酸、雌激素、泼尼松龙等其他药物有有益效果。尽管它们被广泛使用，但仍需要进一步研究以确定最佳治疗方法。黄体期支持的文献综述及已发表研究分析。
