Combs Stephanie E, Sterzing Florian, Uhl Matthias, Habl Gregor, Schubert Kai, Debus Jürgen, Herfarth Klaus
Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
Tumori. 2011 Jul-Aug;97(4):484-91. doi: 10.1177/030089161109700412.
To evaluate helical tomotherapy for the treatment of complex-shaped uni- or multifocal meningiomas.
Between 2007 and 2009, 12 patients with complex-shaped meningiomas and/or multiple meningioma lesions were treated with helical tomotherapy. Histologic classification according to the most recent WHO classification for brain tumors was WHO grade I meningioma in 5 patients, atypical WHO grade II meningioma in 5 patients, and anaplastic WHO grade III meningioma in 2 patients. Eight patients were treated with primary radiotherapy, and in 4 patients tomotherapy was performed as re-irradiation for recurrent tumors.
All patients were alive at the time of this analysis. Treatment was well tolerated by all patients. No severe side effects were observed. Four of 12 patients developed progression during follow-up at 2, 4, 17 and 29 months after radiotherapy. Of these, 2 patients were diagnosed with anaplastic meningiomas, and 2 patients suffered from atypical meningioma. Tumor progression developed after primary radiotherapy in 2 patients, and 2 recurrences developed after re-irradiation.
Helical tomotherapy can help meet the challenge of treating complex-shaped meningiomas in critical locations with one or multiple lesions due to the excellent dose distributions and the favorable clinical results.
评估螺旋断层放射治疗用于治疗形状复杂的单发性或多发性脑膜瘤的效果。
2007年至2009年期间，12例形状复杂的脑膜瘤和/或多发性脑膜瘤病变患者接受了螺旋断层放射治疗。根据世界卫生组织（WHO）最新的脑肿瘤分类进行组织学分类，其中5例为WHO I级脑膜瘤，5例为非典型WHO II级脑膜瘤，2例为间变性WHO III级脑膜瘤。8例患者接受了初次放疗，4例患者接受了螺旋断层放射治疗作为复发性肿瘤的再照射。
在本次分析时，所有患者均存活。所有患者对治疗耐受性良好。未观察到严重副作用。12例患者中有4例在放疗后2、4、17和29个月的随访期间出现病情进展。其中，2例患者被诊断为间变性脑膜瘤，2例患者患有非典型脑膜瘤。2例患者在初次放疗后出现肿瘤进展，2例在再照射后复发。
由于出色的剂量分布和良好的临床效果，螺旋断层放射治疗有助于应对治疗关键部位有一个或多个病变的形状复杂的脑膜瘤的挑战。
