Department of Neurology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Cell Physiol. 2012 Mar;227(3):1269-79. doi: 10.1002/jcp.23048.
The current review focuses on pathophysiology, animal models and molecular analysis of stroke and retinal ischemia, and the role of stem cells in recovery of these disease conditions. Research findings associated with ischemic stroke and retinal ischemia have been discussed, and efforts towards prevention and limiting the recurrence of ischemic diseases, as well as emerging treatment possibilities with endothelial progenitor cells (EPCs) in ischemic diseases, are presented. Although most neurological diseases are still not completely understood and reliable treatment is lacking, animal models provide a major step in validating novel therapies. Stem cell approaches constitute an emerging form of cell-based therapy to treat ischemic diseases since it is an attractive source for regenerative therapy in the ischemic diseases. In this review, we highlight the advantages and limitations of this approach with a focus on key observations from preclinical animal studies and clinical trials. Further research, especially on treatment with EPCs is warranted.
本篇综述聚焦于中风和视网膜缺血的病理生理学、动物模型和分子分析，以及干细胞在这些疾病康复中的作用。文中讨论了与缺血性中风和视网膜缺血相关的研究结果，并介绍了预防和限制缺血性疾病复发的努力，以及内皮祖细胞（EPC）在缺血性疾病中新兴的治疗可能性。尽管大多数神经疾病仍未被完全理解，且缺乏可靠的治疗方法，但动物模型为验证新疗法提供了重要步骤。由于其是缺血性疾病再生疗法的有吸引力的来源，因此干细胞方法构成了治疗缺血性疾病的新兴细胞治疗形式。在本综述中，我们重点介绍了这种方法的优点和局限性，特别强调了临床前动物研究和临床试验的关键观察结果。需要进一步的研究，特别是关于 EPC 治疗的研究。
