Kumar Varun
Department of Ophthalmology, School of Medicine, Stanford University, Stanford, CA, USA.
Open J Ophthalmol. 2017 Nov;7(4):281-292. doi: 10.4236/ojoph.2017.74037. Epub 2017 Nov 6.
Stroke is the fifth leading cause of death and disability in the United States. According to World Heart Federation, every year, 15 million people suffer from stroke worldwide out of which nearly 6 million people die and another 5 million people are disabled. Out of many organs affected after stroke, one of them is eye. Majority of the stroke victims suffer vision loss due to stroke-induced retinal damage. However, stroke-induced retinal damage and microvascular changes have not been given paramount importance in understanding stroke pathophysiology and predicting its occurrence. Retinal imaging can be a very powerful tool to understand and predict stroke. This review will highlight the importance of retinal changes in predicting occurrence of stroke, major retinal changes, the relationship between retinal diseases and stroke and moreover, molecular mechanisms delineating the stroke induced-retinal changes and therapeutics associated with it.
中风是美国导致死亡和残疾的第五大主要原因。根据世界心脏联合会的数据，全球每年有1500万人中风，其中近600万人死亡，另有500万人残疾。中风后受影响的众多器官中，眼睛是其中之一。大多数中风患者因中风引起的视网膜损伤而视力丧失。然而，中风引起的视网膜损伤和微血管变化在理解中风病理生理学和预测其发生方面并未得到足够重视。视网膜成像可能是理解和预测中风的一个非常有力的工具。本综述将重点介绍视网膜变化在预测中风发生中的重要性、主要的视网膜变化、视网膜疾病与中风之间的关系，此外，还将阐述中风诱导视网膜变化的分子机制以及与之相关的治疗方法。
