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披着羊皮的狼:急性髓细胞白血病伪装成硬脑膜下血肿。

Wolf in sheep's clothing: acute chloroma disguised as a subdural hematoma.

机构信息

Department of Neurosurgery, Mayo Clinic, Rochester, MN 55905, USA.

出版信息

Neurocrit Care. 2012 Feb;16(1):148-50. doi: 10.1007/s12028-011-9631-7.

DOI:10.1007/s12028-011-9631-7
PMID:21989841
Abstract

BACKGROUND

Subdural hematomas are not infrequent among patients with hematologic disorders as they are prone to thrombocytopenia from their disease and chemotherapy. However, rarely these patients can also have leukemic involvement of the subdural space.

METHODS

Case Report with CT scan and intraoperative photographs.

RESULTS

A 45-year-old woman with acute myeloid leukemia presented with progressive headache, somnolence, and hemiparesis. She was noted to be thrombocytopenic. CT scan revealed a heterodense extra-axial lesion consistent with an acute to subacute subdural hematoma. There was no antecedent trauma. After platelet transfusion, she was taken for burr hole evacuation and an opalescent pearly white mass was encountered. Pathology revealed myeloid sarcoma.

CONCLUSIONS

Myeloid sarcoma can mimic subdural hematoma both clinically and radiologically. It should be considered when a patient with a prior leukemia and no antecedent trauma presents with an extra-axial lesion.

摘要

背景

患有血液疾病的患者容易因疾病和化疗导致血小板减少,因此硬膜下血肿并不少见。然而,这些患者的硬膜下腔也很少会发生白血病浸润。

方法

病例报告并附有 CT 扫描和术中照片。

结果

一名 45 岁女性患有急性髓细胞性白血病,表现为进行性头痛、嗜睡和偏瘫。她被发现血小板减少。CT 扫描显示一个异密度的外轴病变,符合急性至亚急性硬膜下血肿。没有先前的创伤。血小板输注后,她接受了颅骨钻孔清除术,遇到了乳白色的珍珠白色肿块。病理显示髓样肉瘤。

结论

髓样肉瘤在临床和影像学上均可模拟硬膜下血肿。当有先前白血病且无先前创伤的患者出现外轴病变时,应考虑髓样肉瘤。

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Neurocrit Care. 2012 Feb;16(1):148-50. doi: 10.1007/s12028-011-9631-7.
2
Intracranial granulocytic sarcoma (chloroma) may mimic a subdural hematoma.颅内粒细胞肉瘤(绿色瘤)可能酷似硬膜下血肿。
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Unravelling chloroma: review of imaging findings.解析绿色瘤:影像学表现综述
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Diagnosis in subdural myeloid sarcoma.硬脑膜下髓系肉瘤的诊断

本文引用的文献

1
Granulocytic sarcoma in a patient with blast crisis mimicking a chronic subdural hematoma.一名处于原始细胞危象的患者出现类似慢性硬膜下血肿的粒细胞肉瘤。
J Clin Oncol. 2011 Jul 1;29(19):e569-71. doi: 10.1200/JCO.2010.33.1272. Epub 2011 May 9.
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Prognostic factors of treatment outcomes in patients with granulocytic sarcoma.粒细胞肉瘤患者治疗结局的预后因素
Acta Haematol. 2009;122(4):238-46. doi: 10.1159/000253592. Epub 2009 Oct 30.
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Myeloid sarcoma: extramedullary manifestation of myeloid disorders.髓系肉瘤:髓系疾病的髓外表现。
Neuroradiol J. 2017 Jun;30(3):269-273. doi: 10.1177/1971400916689343. Epub 2017 Jan 30.
Am J Clin Pathol. 2009 Sep;132(3):426-37. doi: 10.1309/AJCP1ZA7HYZKAZHS.
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Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia.与急性髓系白血病相比,髓系肉瘤的无事件生存期和总生存期更长。
Cancer. 2008 Sep 15;113(6):1370-8. doi: 10.1002/cncr.23691.
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Intracranial myeloid sarcoma: conventional and advanced MRI findings.颅内髓系肉瘤:传统及高级MRI表现
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Intracranial granulocytic sarcoma (chloroma) may mimic a subdural hematoma.颅内粒细胞肉瘤(绿色瘤)可能酷似硬膜下血肿。
J Neurol. 2005 Apr;252(4):498-9. doi: 10.1007/s00415-005-0680-8. Epub 2005 Feb 23.
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CT changes of an intracranial granulocytic sarcoma on short-term follow-up.颅内粒细胞肉瘤短期随访的CT变化
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Unusual cause of extradural haemorrhage.硬膜外出血的罕见病因。
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Granulocytic sarcoma in childhood leukemia: imaging features.儿童白血病中的粒细胞肉瘤:影像学特征
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