Vaughan Simon, Jat Parmjit S
Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
Aging (Albany NY). 2011 Oct;3(10):913-9. doi: 10.18632/aging.100390.
Cellular senescence is a program of irreversible cell cycle arrest that cells undergo in response to a variety of intrinsic and extrinsic stimuli including progressive shortening of telomeres, changes in telomeric structure or other forms of genotoxic and non-genotoxic stress. The role of nuclear factor-κB in cellular senescence is controversial, as it has been associated with both proliferation and tumour progression, and also with growth arrest and ageing. This research perspective focuses on the evidence for a functional relationship between NF-κB and senescence, and how disruption of the NF-κB pathway can lead to its bypass.
细胞衰老指细胞经历的一种不可逆的细胞周期停滞程序，该程序是细胞对包括端粒逐渐缩短、端粒结构变化或其他形式的基因毒性和非基因毒性应激在内的多种内在和外在刺激所做出的反应。核因子κB在细胞衰老中的作用存在争议，因为它既与细胞增殖和肿瘤进展有关，也与生长停滞和衰老有关。本研究视角聚焦于核因子κB与衰老之间功能关系的证据，以及核因子κB信号通路的破坏如何导致其被绕过。
