Department of Physical Therapy, Leiden University Medical Center, The Netherlands.
Pediatr Blood Cancer. 2012 Jun;58(6):978-85. doi: 10.1002/pbc.23328. Epub 2011 Oct 11.
Few longitudinal data are available concerning quality of life (QoL) and functioning of young patients undergoing surgical procedures for malignant bone tumors around the knee joint. Aim of the present study was to evaluate patients' quality of life, functional ability, and physical activity during a 2-year postoperative period.
This prospective study included patients who underwent surgery for a malignant bone tumor around the knee joint between 2004 and 2008. Assessments were done at 3, 6, 9, 12, 18, and 24 months after surgery. QoL was measured with the TNO-AZL Children's or Adult's Quality of Life Questionnaires (TACQOL and TAAQOL), the Short Form-36 (SF-36) and Bone tumor (Bt)-DUX; functional ability with the Toronto Extremity Salvage Scale (TESS), the 6-minute walk test (6 MWT) and four functional performance tests; and physical activity with the Baecke questionnaire and the ActiLog® activity monitor. Statistical analysis included linear mixed model analysis.
Forty-four patients (27 males, 17 females, mean age 14.9 (SD 4.8) years) were included, 27 (61%) underwent limb-salvage and 17 (39%) ablative surgery. Twenty patients were lost during the 2 years follow-up as a consequence of oncological complications. Over the first year, survivors showed significant improvement of QoL, functional ability and physical activity, except for the mental dimension of the SF-36 and the activity monitor results. Over the second year, these improvements were less pronounced.
In the first 2 years after bone tumor surgery, survivors improved significantly with respect to QoL, functional ability, and physical activity levels.
膝关节周围恶性骨肿瘤患者行外科手术治疗后，仅有少量纵向数据可用于评估其生活质量（QoL）和功能。本研究旨在评估患者术后 2 年内的生活质量、功能能力和身体活动情况。
该前瞻性研究纳入了 2004 年至 2008 年间接受膝关节周围恶性骨肿瘤手术的患者。术后 3、6、9、12、18 和 24 个月进行评估。使用 TNO-AZL 儿童或成人生活质量问卷（TACQOL 和 TAAQOL）、SF-36 量表和骨肿瘤（Bt）-DUX 量表评估生活质量，使用多伦多四肢挽救评分（TESS）、6 分钟步行测试（6MWT）和 4 项功能表现测试评估功能能力，使用 Baecke 问卷和 ActiLog®活动监测仪评估身体活动情况。统计分析采用线性混合模型分析。
共纳入 44 例患者（男 27 例，女 17 例，平均年龄 14.9 [4.8] 岁），27 例行保肢手术，17 例行根治性手术。20 例患者因肿瘤相关并发症在 2 年随访期间失访。幸存者在术后第 1 年 QoL、功能能力和身体活动水平显著改善，除了 SF-36 的心理维度和活动监测仪结果外。在第 2 年，这些改善不那么明显。
膝关节周围恶性骨肿瘤患者术后前 2 年，幸存者的生活质量、功能能力和身体活动水平显著提高。
