Bekkering W Peter, Vlieland Theodora P M Vliet, Koopman Hendrik M, Schaap Gerard R, Schreuder H W Bart, Beishuizen Auke, Tissing Wim J E, Hoogerbrugge Peter M, Anninga Jacob K, Taminiau Antonie H M
Department of Physical Therapy, Leiden University Medical Center, Leiden, The Netherlands.
Pediatr Blood Cancer. 2009 Sep;53(3):348-55. doi: 10.1002/pbc.22078.
To examine the practical applicability, internal consistency, and validity of the Bt-DUX, a disease-specific Health Related Quality of Life (HRQoL) instrument. The Bt-Dux was developed to examine patients' individual values of their life after a malignant bone tumor of the lower extremity at four domains (cosmetic, social, emotional, and functional).
Patients were eligible for this cross-sectional, multicenter study if they underwent surgery for a malignant tumor of the leg in a period ranging between 12 and 60 months before the recruitment. Assessments included: Bt-DUX, Toronto Extremity Salvage Score (TESS) Short Form (SF)-36, TNO-AZL Questionnaire for Adult's Quality of Life (TAAQOL), and TNO-AZL Children's Quality of Life Questionnaire (TACQOL).
Seventy-two patients (35 male, 37 female), mean age 17 (SD 4) years were included. Limb sparing surgery took place in 32 patients and ablative surgery in 40 patients. The Bt-DUX was completed in less than 5 min and easy to comprehend. The mean Bt-DUX score was 69.8 (SD 15.5), with Cronbach's alpha being 0.92. Domain-total correlations ranged between 0.84 and 0.88 (P < 0.01). Correlations between Bt-DUX Total score and TESS, SF-36 Physical and Mental Component Summary scales and selected TACQOL and TAAQOL scores were statistically significant (P < 0.05), except for the social scale of the TACQOL. The Bt-DUX was able to discriminate between patients with higher and lower TESS scores (P < 0.05).
The Bt-DUX was found to be a practical and valid instrument. Its added value compared with existing HRQoL measures needs to be further established.
为检验特定疾病的健康相关生活质量（HRQoL）工具——Bt-DUX的实际适用性、内部一致性和有效性。开发Bt-DUX是为了在四个领域（外观、社交、情感和功能）评估下肢恶性骨肿瘤患者对其生活的个人价值观。
如果患者在招募前12至60个月期间接受了腿部恶性肿瘤手术，则符合这项横断面多中心研究的条件。评估包括：Bt-DUX、多伦多肢体挽救评分（TESS）简表（SF）-36、TNO-AZL成人生活质量问卷（TAAQOL）和TNO-AZL儿童生活质量问卷（TACQOL）。
纳入72例患者（男性35例，女性37例），平均年龄17（标准差4）岁。32例患者接受了保肢手术，40例患者接受了截肢手术。Bt-DUX在不到5分钟内即可完成，且易于理解。Bt-DUX平均得分为69.8（标准差15.5），克朗巴哈系数为0.92。领域总分相关性在0.84至0.88之间（P<0.01）。Bt-DUX总分与TESS、SF-36身体和心理成分汇总量表以及选定的TACQOL和TAAQOL得分之间的相关性具有统计学意义（P<0.05），TACQOL的社交量表除外。Bt-DUX能够区分TESS得分较高和较低的患者（P<0.05）。
发现Bt-DUX是一种实用且有效的工具。与现有HRQoL测量方法相比，其附加值有待进一步确定。
