Department of Interventional Neuroradiology/Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
J Neurointerv Surg. 2011 Dec 1;3(4):358-60. doi: 10.1136/jnis.2010.004382. Epub 2011 Feb 18.
Dual antiplatelet therapy is established for prevention of stent thrombosis in cardiac patients, and widely utilized in neurointerventional stent cases. Aspirin and clopidogrel are typically synergistic. We present a case of clopidogrel resistance due to genetic polymorphism resulting in acute stent thrombosis during elective stent-assisted coiling, with novel use of prasugrel as an alternative platelet inhibitor in the neurovascular setting.
双联抗血小板治疗已被确立用于预防心脏患者的支架血栓形成，并广泛应用于神经介入支架病例中。阿司匹林和氯吡格雷通常具有协同作用。我们报告了一例由于遗传多态性导致氯吡格雷抵抗的病例，在择期支架辅助弹簧圈治疗中发生急性支架内血栓形成，新型血小板抑制剂普拉格雷在神经血管环境中的应用。
