Valor Medical Inc, San Diego, California 92121, USA.
J Neurointerv Surg. 2012 Sep;4(5):379-84. doi: 10.1136/neurintsurg-2011-010094. Epub 2011 Oct 4.
The need for medical grade tissue adhesives both in surgery and to treat trauma has become well established. Such a device has been developed and preliminary toxicity testing completed on a compounded cyanoacrylate (Neucrylate), and its properties have been modified so it may be used as an intravascular embolic agent. Given the high incidence of iatrogenic infections in hospital, it would be desirable to have such an implantable device that inhibits dangerous bacteria.
Seven separate cultures of common bacteria were grown and exposed to Neucrylate. The impact on the exposed microorganisms was analyzed visually as well as by means of fluorescence and optical microscopy.
The device produced high degrees of antibacterial effect when exposed to gram positive bacteria whereas it had modest impact on gram negative bacteria.
在外科手术和创伤治疗中，都需要使用医用级别的组织粘合剂。目前已经开发出一种新型化合物氰基丙烯酸酯（Neucrylate），并已完成初步毒性测试，其性能已得到改进，可作为一种血管内栓塞剂使用。鉴于医院内医源性感染的发生率很高，如果有一种可植入的、能抑制危险细菌的设备，那将是非常理想的。
培养了七种常见细菌的单独培养物，并将其暴露于 Neucrylate 中。通过肉眼观察、荧光和光学显微镜分析了暴露于 Neucrylate 对微生物的影响。
该设备在暴露于革兰氏阳性菌时产生了高度的抗菌效果，而对革兰氏阴性菌的影响则较为温和。
