Lee S P
University of Washington, Seattle.
Clin Ther. 1990 May-Jun;12(3):194-9.
Research on gallstone formation has been focused on the role of supersaturated bile in cholesterol gallstone disease. But now investigators have advanced the concept of nucleation, which holds that the interaction of pronucleators and antinucleators is responsible for the formation of cholesterol crystals and the subsequent development of gallstones. Ultrasonography can identify biliary sludge, the chemical composition of which appears to depend on the type of medical disorder present. The chemical composition of sludge will determine the composition of the gallstones--either cholesterol stones or pigment stones--that eventually form. Nonsurgical interventions, such as bile acids, are effective in the treatment of cholesterol gallstones, which account for approximately 80% of cases that develop in Western populations. Bile acids are not effective in treating calcium bilirubinate stones.
胆结石形成的研究一直聚焦于过饱和胆汁在胆固醇结石疾病中的作用。但现在研究人员提出了成核的概念，即认为促核因子和抗核因子的相互作用是胆固醇晶体形成及随后胆结石发展的原因。超声检查能够识别胆泥，其化学成分似乎取决于所患疾病的类型。胆泥的化学成分将决定最终形成的胆结石（胆固醇结石或色素结石）的成分。非手术干预措施，如胆汁酸，对胆固醇结石的治疗有效，胆固醇结石约占西方人群所患病例的80%。胆汁酸对治疗胆红素钙结石无效。
