Wang Z, Yin Z
Department of Cardio-Endocrinology, Tianjin No 2 Hospital.
Zhong Xi Yi Jie He Za Zhi. 1990 Mar;10(3):137-40, 130.
Radioimmunoassay methods were modified for insulin(IRI), C-peptide (IRCP) and glucagon (IRG) in the clinical investigation on normal subjects and 38 patients with non-insulin-dependent diabetes mellitus (NIDDM). In the control group, the peaks of glucose and IRI appeared 1 hour after glucose was taken. IRCP peak, however, appeared 1 hour later. IRG showed its maximum value on fasting and then reached its lowest point at the second hour after glucose loading. The authors' interests were focused on the changes of blood glucose, IRI, IRCP, and IRG in oral glucose tolerance test (OGTT) before and after Ke-Tang-Ling (KTL) was administered in NIDDM. The results demonstrate that the glucose levels and undercure areas at various phases in OGTT were significantly decreased (P less than 0.01) in comparison of before and after the treatment with KTL in NIDDM (including obese and non-obese groups). In non-obese group, however, IRI, IRCP, and their undercure were remarkably increased (P less than 0.01). In obese group their values were decreased. It suggests that KTL plays a therapeutic role in decreasing blood glucose in non-obese NIDDM. The mechanism involved in this process may be related to its stimulating effect. IRG levels were decreased also (P less than 0.01) after the treatment with KTL in both obese and non-obese NIDDM, suggesting an inhibitory effect on glucagon secretion from alpha cells in pancrease.
对放射免疫分析方法进行了改进，用于对正常受试者和38例非胰岛素依赖型糖尿病（NIDDM）患者进行胰岛素（IRI）、C肽（IRCP）和胰高血糖素（IRG）的临床研究。在对照组中，服用葡萄糖1小时后血糖和IRI出现峰值。然而，IRCP峰值在1小时后出现。IRG在空腹时显示最大值，然后在葡萄糖负荷后第2小时达到最低点。作者关注的是在NIDDM患者中服用克糖灵（KTL）前后口服葡萄糖耐量试验（OGTT）中血糖、IRI、IRCP和IRG的变化。结果表明，与NIDDM患者（包括肥胖和非肥胖组）服用KTL治疗前后相比，OGTT各阶段的血糖水平和曲线下面积显著降低（P<0.01）。然而，在非肥胖组中，IRI、IRCP及其曲线下面积显著增加（P<0.01）。在肥胖组中，它们的值降低。这表明KTL在降低非肥胖NIDDM患者血糖方面发挥治疗作用。这一过程涉及的机制可能与其刺激作用有关。在肥胖和非肥胖NIDDM患者中，服用KTL治疗后IRG水平也降低（P<0.01），表明对胰腺α细胞分泌胰高血糖素有抑制作用。
