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本文引用的文献

1
Omega-3 free fatty acids for the maintenance of remission in Crohn disease: the EPIC Randomized Controlled Trials.欧米伽-3游离脂肪酸用于维持克罗恩病缓解:EPIC随机对照试验
JAMA. 2008 Apr 9;299(14):1690-7. doi: 10.1001/jama.299.14.1690.
2
Drug interactions in inflammatory bowel disease.炎症性肠病中的药物相互作用。
Am J Gastroenterol. 2008 Jan;103(1):207-19; quiz 206, 220. doi: 10.1111/j.1572-0241.2007.01559.x. Epub 2007 Dec 11.
3
Lack of pharmacokinetic interaction between St. John's wort and prednisone.圣约翰草与泼尼松之间不存在药代动力学相互作用。
Ann Pharmacother. 2007 Nov;41(11):1819-24. doi: 10.1345/aph.1K316. Epub 2007 Oct 9.
4
Dose-dependent influence of 5-aminosalicylates on thiopurine metabolism.5-氨基水杨酸酯对硫嘌呤代谢的剂量依赖性影响。
Am J Gastroenterol. 2007 Dec;102(12):2747-53. doi: 10.1111/j.1572-0241.2007.01511.x. Epub 2007 Aug 31.
5
Age at onset of inflammatory bowel disease and the risk of surgery for non-neoplastic bowel disease.炎症性肠病的发病年龄与非肿瘤性肠病的手术风险
Aliment Pharmacol Ther. 2007 Jun 15;25(12):1435-41. doi: 10.1111/j.1365-2036.2007.03341.x.
6
Effect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.别嘌醇对硫唑嘌呤或6-巯基嘌呤治疗无效的炎症性肠病患者临床结局的影响。
Clin Gastroenterol Hepatol. 2007 Feb;5(2):209-14. doi: 10.1016/j.cgh.2006.11.020.
7
5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review.5-氨基水杨酸酯与炎症性肠病的肾功能:一项系统评价
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Problems encountered during anti-tumour necrosis factor therapy.抗肿瘤坏死因子治疗期间遇到的问题。
Best Pract Res Clin Rheumatol. 2006 Aug;20(4):757-90. doi: 10.1016/j.berh.2006.06.002.
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Drug interactions during therapy with three major groups of antimicrobial agents.三大类抗菌药物治疗期间的药物相互作用。
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Clinically relevant drug interactions with antiepileptic drugs.抗癫痫药物的临床相关药物相互作用。
Br J Clin Pharmacol. 2006 Mar;61(3):246-55. doi: 10.1111/j.1365-2125.2005.02529.x.

老年炎症性肠病:警钟敲响。

Inflammatory bowel disease of the elderly: a wake-up call.

作者信息

Katz Seymour, Feldstein Richard

机构信息

Dr. Katz serves as Clinical Professor of Medicine at the New York University School of Medicine in New York, New York, and as an Attending Gastroenterologist at North Shore University Hospital-Long Island Jewish Medical Center in Manhasset, New York.

出版信息

Gastroenterol Hepatol (N Y). 2008 May;4(5):337-47.

PMID:21990970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3093721/
Abstract

As the baby-boomer generation enters the ranks of the elderly (defined as patients over 60 years of age), the increased burden of managing older inflammatory bowel disease (IBD) patients requires recognition of the impact of comorbid disease, polypharmacy, and surgical candidacy criteria. There is a surprisingly positive response to newer therapies and surgery, provided that a distinction is made between "fit elderly" and "frail elderly" patients. The former group should not be denied access to the newer biologics, clinical trials, or surgical alternatives on the basis of age alone. There is a need for clinicians caring for elderly IBD patients to be cognizant of the multiple and often disguised conditions contributing to disease management as well as the importance for careful allocation of health resources.

摘要

随着婴儿潮一代步入老年(定义为60岁以上的患者),管理老年炎症性肠病(IBD)患者的负担日益加重,这就需要认识到合并症、多种药物治疗以及手术候选标准的影响。只要区分“健康老年人”和“体弱老年人”患者,对新疗法和手术就会有出人意料的积极反应。不应仅基于年龄而拒绝前一组患者使用新型生物制剂、参加临床试验或选择手术替代方案。照顾老年IBD患者的临床医生需要认识到导致疾病管理的多种且常常隐匿的状况,以及谨慎分配医疗资源的重要性。