Yarets Y I, Novikova I A, Rubanov L N
Laboratory Medicine Department of Gomel State Medical University, Republic of Belarus.
Ann Burns Fire Disasters. 2009 Dec 31;22(4):179-84.
Background. Surgical interference which includes debridement and further renewal of skin cover by autodermoplasty (ADP) is the most effective method of burn wound treatment. Skin graft failure is a serious complication of ADP procedures leading to the opening of previously closed wounds, graft loss, and an increased wound surface owing to the donor zone. Numerous factors are involved that may affect the results of the ADP procedure. When planning the terms of surgical interference, specialists have to take into consideration criteria regarding the visual readiness of the wound and the patient's objective state. Aim. We studied the possibility of using concentrations of trien conjugates, Schiff bases, and ceruloplasmin in the plasma of patients with deep local wounds as markers of the risk of autoskin graft failure. Methods. Ninety patients with local wounds of different origin and age were studied. Results and conclusions. It was found out that the amounts of trien conjugates, Schiff bases, and ceruloplasmin in plasma before the operation helped to predict the risk of autoskin graft failure with a high degree of probability (up to 92%). We established optimum cut-off points for trien conjugates, Schiff bases, and ceruloplasmin as indicators of the results of autodermoplasty operations, i.e. 350 mg/l, 0.35 units of oxidation indices (UOI), and 0.05 UOI, respectively.
背景。手术干预，包括清创术以及通过自体皮肤移植术（ADP）进一步更新皮肤覆盖，是烧伤创面治疗最有效的方法。皮肤移植失败是ADP手术的一种严重并发症，会导致先前闭合的伤口裂开、移植皮片丢失，并且由于供皮区导致创面增大。有许多因素可能会影响ADP手术的结果。在规划手术干预的时机时，专家们必须考虑伤口外观愈合程度和患者客观状态等标准。目的。我们研究了将深部局部伤口患者血浆中三烯共轭物、席夫碱和铜蓝蛋白的浓度作为自体皮肤移植失败风险标志物的可能性。方法。对90例不同病因和年龄的局部伤口患者进行了研究。结果与结论。发现术前血浆中三烯共轭物、席夫碱和铜蓝蛋白的含量有助于高度准确地预测自体皮肤移植失败的风险（高达92%）。我们确定了三烯共轭物、席夫碱和铜蓝蛋白作为自体皮肤移植手术结果指标的最佳截断点，分别为350毫克/升、0.35氧化指数单位（UOI）和0.05 UOI。
