Gospodarowicz D
Cancer Research Institute, University of California, San Francisco 94143.
Clin Orthop Relat Res. 1990 Aug(257):231-48.
Basic and acidic fibroblast growth factor (FGF) are two closely related growth factors that interact with the same receptor. Structurally related to FGF are five different oncogenes that have been involved in mammary, stomach, and bladder cancers but whose precise functions in physiologic processes are presently unknown. Both basic and acidic FGF exert similar biologic effects on a wide range of mesoderm- and neuroectoderm-derived cells, acting both as morphogens and mitogens. In addition, basic FGF has been shown to act as a ventrovegetalizing factor, inducing, at the midblastulae stage, mesoderm formation from animal pole cells destined to form ectodermal structures. This primordial role explains the wide variety of tissues, ranging from the central and peripheral nervous system to the vascular system, that are affected by FGF during the late embryonic, neonatal, and adult phases of development.
碱性成纤维细胞生长因子（FGF）和酸性成纤维细胞生长因子是两种密切相关的生长因子，它们与同一受体相互作用。与FGF结构相关的有五种不同的癌基因，它们与乳腺癌、胃癌和膀胱癌有关，但目前其在生理过程中的精确功能尚不清楚。碱性和酸性FGF对多种中胚层和神经外胚层来源的细胞都发挥相似的生物学作用，兼具形态发生素和促有丝分裂原的功能。此外，碱性FGF已被证明可作为腹侧内胚层化因子，在囊胚中期诱导注定形成外胚层结构的动物极细胞形成中胚层。这一原始作用解释了在胚胎后期、新生儿期和成年期发育过程中，从中枢和外周神经系统到血管系统等多种组织受到FGF影响的原因。
