Robson M C, Stenberg B D, Heggers J P
Division of Plastic Surgery, University of Texas Medical Branch, Shriners Burns Institute, Galveston, Texas.
Clin Plast Surg. 1990 Jul;17(3):485-92.
The theoretical alterations of wound healing caused by infection apply to the clinical situation. The level of bacteria is clinically important as are the specific qualities of a given species. This latter consideration has not been as completely studied as have the quantitative aspects. However, as pharmacologic means of overcoming the wound healing alterations are sought, specific bacterial species' idiosyncrasies will have to be examined. This has already been identified for the beta-hemolytic streptococcus. That species has not adhered to the level of greater than 10(5) organisms to produce wound complications. It has been repeatedly shown to cause wound problems at a much lower inoculum. Similar information may become available for other organisms. However, it is clear that because wound healing in the clinical situation occurs in the presence of bacteria, it is important to be aware of potential alterations in the repair process that these bacteria can cause.
感染引起的伤口愈合理论变化适用于临床情况。细菌数量在临床上很重要，特定菌种的特性同样如此。后一个因素的研究不如定量方面那么全面。然而，在寻求克服伤口愈合变化的药理学方法时，必须研究特定细菌种类的特质。这一点已在β-溶血性链球菌中得到证实。该菌种在菌量大于10⁵时不会引发伤口并发症。但反复证明，接种量低得多时它也会导致伤口问题。其他微生物可能也会有类似情况。然而，很明显，由于临床情况下伤口愈合是在有细菌的环境中发生的，所以了解这些细菌可能导致的修复过程潜在变化很重要。
