一种用于伤口愈合的生物相容性聚丙烯酸-铜-金属有机框架水凝胶。
A biocompatible PAA-Cu-MOP hydrogel for wound healing.
作者信息
Chen Linlin, Qin Yu, Cheng Jing, Cheng Yi, Lu Zhixiang, Liu Xiaolan, Yang Shaoxiong, Lu Shuhan, Zheng Liyan, Cao Qiue
机构信息
School of Pharmacy, QuanZhou Medical College Quanzhou Fujian 362000 China.
Key Laboratory of Medicinal Chemistry for Natural Resource, Functional Molecules Analysis and Biotransformation Key Laboratory of Universities in Yunnan Province, School of Chemical Science and Technology, Yunnan University Kunming 650091 China.
出版信息
RSC Adv. 2020 Oct 1;10(59):36212-36218. doi: 10.1039/c9ra10031h. eCollection 2020 Sep 28.
Wounds infected by bacteria are dangerous for human beings. However, along with the emergence of new strains and strong bacterial resistance, traditional antibiotics are unable to meet the medical needs for treating bacterial infections. Thus, new antibacterial substances with superior antimicrobial properties are urgently needed. Herein, a hydrogel containing poly acrylic acid (PAA), glycerol and Cu-MOP (named PAA-Cu-MOP hydrogel) is obtained by a facile mixing and ultrasonic procedure for wound healing treatment. This PAA-Cu-MOP hydrogel with high biocompatibility exhibits excellent wound healing behavior and is even better than the one of recombinant human epidermal growth factor. Tissue experiment results reveal that the PAA-Cu-MOP hydrogel accelerates the wound healing process by promoting angiogenesis, stimulating cell proliferation, and up-regulating cell factors.
被细菌感染的伤口对人类来说是危险的。然而，随着新菌株的出现和细菌耐药性的增强，传统抗生素已无法满足治疗细菌感染的医疗需求。因此，迫切需要具有卓越抗菌性能的新型抗菌物质。在此，通过简便的混合和超声程序制备了一种含有聚丙烯酸（PAA）、甘油和金属有机框架铜（Cu-MOP）的水凝胶（命名为PAA-Cu-MOP水凝胶）用于伤口愈合治疗。这种具有高生物相容性的PAA-Cu-MOP水凝胶表现出优异的伤口愈合性能，甚至优于重组人表皮生长因子。组织实验结果表明，PAA-Cu-MOP水凝胶通过促进血管生成、刺激细胞增殖和上调细胞因子来加速伤口愈合过程。
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