曾吸烟的稳定期慢性阻塞性肺疾病患者鼻黏膜纤毛清除功能受损与存在慢性支气管炎表型有关。
Impairment of nasal mucociliary clearance in former smokers with stable chronic obstructive pulmonary disease relates to the presence of a chronic bronchitis phenotype.
机构信息
Pulmonary Department, Charles University in Prague, Czech Republic.
出版信息
Rhinology. 2011 Oct;49(4):397-406. doi: 10.4193/Rhino11.051.
BACKGROUND
Associations between nasal and bronchial impairment have been repeatedly described in chronic obstructive pulmonary disease (COPD), whereas nasal mucociliary clearance (MCC) in COPD patients is not yet fully understood. We studied nasal MCC parameters in COPD patients and compared them with healthy adults (HA) and with cystic fibrosis (CF) patients with compromised MCC.
METHODOLOGY
An observational study of 98 COPD ex-smokers and subjects from control groups evaluated for nasal MCC time (NMCCt) and by digital video microscopy of nasal mucosa recording ciliary beat frequency (CBF) and ciliary beat pattern.
RESULTS
The NMCCt was decreased in HA compared to those with COPD and decreased in those with COPD compared to those with CF. CBF in COPD was lower compared to HA. The index of ciliary dyskinesia in COPD patients differed from HA. We detected higher NMCCt and lower nasal CBF in patients with chronic bronchitis phenotype (CB) compared to non-CB patients.
CONCLUSIONS
We confirmed the presence of impaired nasal MCC in COPD ex-smokers. These impairments were apparent predominantly in the CB phenotype.
背景
在慢性阻塞性肺疾病（COPD）中，鼻腔和支气管损害之间的关联已被反复描述，而 COPD 患者的鼻腔黏膜纤毛清除（MCC）尚未得到充分理解。我们研究了 COPD 患者的鼻腔 MCC 参数，并将其与健康成年人（HA）和 MCC 受损的囊性纤维化（CF）患者进行了比较。
方法
一项对 98 名 COPD 戒烟者和对照组受试者的观察性研究评估了鼻腔 MCC 时间（NMCCt），并通过记录纤毛摆动频率（CBF）和纤毛摆动模式的鼻黏膜数字视频显微镜进行了评估。
结果
HA 组的 NMCCt 低于 COPD 组，而 COPD 组的 NMCCt 低于 CF 组。与 HA 相比，COPD 患者的 CBF 较低。COPD 患者的纤毛运动障碍指数与 HA 不同。与非 CB 患者相比，我们在慢性支气管炎表型（CB）患者中检测到更高的 NMCCt 和更低的鼻腔 CBF。
结论
我们证实了 COPD 戒烟者存在鼻腔 MCC 受损。这些损害主要表现在 CB 表型中。
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