Gołab Krzysztof, Passowicz-Muszyńska Ewa, Jankowska Renata, Warwas Maria
Department of Pharmaceutical Biochemistry, Medical University of Wrocław, Poland.
Pol Merkur Lekarski. 2011 Sep;31(183):179-82.
Sarcoidosis is a multisystemic granulomatous disorder of unknown etiology, which is characterized by a variable clinical presentation and course. The diagnosis of this disease is usually supported by the three elements: compatible clinical and radiologic findings, tissue biopsy specimen that reveals noncaseating epithelioid granulomas and the absence of known granulomagenic agent. During the last years the new diagnostic methods have been discovered, but serum markers of the sarcoidosis are still under studying. Among the potential markers of sarcoidosis, a recently proposed indicator is chitotriosidase, a chitinase produced by chronically activated macrophages. The review of the literature showed that chitotriosidase activity is only a surrogate biomarker to confirm diagnosis, but is a useful marker for disease activity monitoring and prognosis. The correlation with the radiological stages of disease suggest that determination of chitotriosidase activity could decrease the number of X-ray examination.
结节病是一种病因不明的多系统肉芽肿性疾病，其临床表现和病程各异。该疾病的诊断通常依据以下三个要素：相符的临床和影像学表现、显示非干酪样上皮样肉芽肿的组织活检标本以及不存在已知的肉芽肿形成因子。在过去几年中，已发现新的诊断方法，但结节病的血清标志物仍在研究中。在结节病的潜在标志物中，最近提出的一个指标是壳三糖苷酶，一种由慢性激活的巨噬细胞产生的几丁质酶。文献综述表明，壳三糖苷酶活性只是用于确诊的替代生物标志物，但对于疾病活动监测和预后是一个有用的标志物。与疾病放射学分期的相关性表明，测定壳三糖苷酶活性可减少X线检查的次数。
