Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin, 150040, P. R. China.
J Org Chem. 2011 Nov 18;76(22):9507-13. doi: 10.1021/jo2017108. Epub 2011 Oct 20.
The palladium-catalyzed intramolecular C-H activation/C-C cross-coupling has been developed for a straightforward and efficient synthesis of phenanthridines. With Pd(OAc)(2) (4 mol %) as the catalyst, PCy(3) (8 mol %) as the ligand, and Cs(2)CO(3) as the base, this protocol was applied to synthesize a small library of phenanthridine derivatives in good yields in THF.
钯催化的分子内 C-H 活化/C-C 交叉偶联反应已被开发用于直接、高效地合成菲啶。以 Pd(OAc)(2)（4 mol %）为催化剂、PCy(3)（8 mol %）为配体、Cs(2)CO(3)为碱，该反应在四氢呋喃中以良好的收率合成了一系列小的菲啶衍生物。
