Ren Hongjun, Li Zhuo, Knochel Paul
Ludwig-Maximilians-Universität München, Department Chemie und Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Germany.
Chem Asian J. 2007 Mar 5;2(3):416-33. doi: 10.1002/asia.200600398.
Condensed N-heterocycles were prepared by using C-H activation reactions catalyzed by Pd(OAc)2 (5 mol %) and (p-tolyl)3P (10 mol %). The key step of these ring closures is chemoselective intramolecular C-H activation of the methyl group at position 2 of the pyrrole ring. Functionalized 9H-pyrrolo[1,2-a]indoles and pyrrolo[1,2-f]phenanthridine derivatives were prepared in good yields. The preparation of some complex N-heterocycles by using successive reactions is also described.
通过使用由醋酸钯（5摩尔%）和对甲苯基膦（10摩尔%）催化的C-H活化反应制备了稠合N-杂环。这些环化反应的关键步骤是吡咯环2位甲基的化学选择性分子内C-H活化。以良好的产率制备了功能化的9H-吡咯并[1,2-a]吲哚和吡咯并[1,2-f]菲啶衍生物。还描述了通过连续反应制备一些复杂N-杂环的方法。
