手性非外消旋胺的一锅合成。
One-pot synthesis of chiral nonracemic amines.
机构信息
School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.
出版信息
J Org Chem. 2011 Nov 18;76(22):9452-9. doi: 10.1021/jo201849j. Epub 2011 Oct 18.
PMID:21992680
Abstract
One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.
摘要
一步法五组分反应，将氧杂硫氮杂环戊烷-S-氧化物与均三甲基溴化镁、双(三甲基硅基)酰胺锂、醛和格氏试剂反应，以良好的收率和高立体选择性得到手性非外消旋胺或亚磺酰胺。
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