手性非外消旋胺的一锅合成。

School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.

J Org Chem. 2011 Nov 18;76(22):9452-9. doi: 10.1021/jo201849j. Epub 2011 Oct 18.

One-pot five-component reactions of oxathiazolidine-S-oxides with mesitylmagnesium bromide, lithium bis(trimethylsilyl)amide, aldehydes and Grignard reagents afford chiral nonracemic amines or sulfinamides in good yields and high stereoselectivities.

一步法五组分反应，将氧杂硫氮杂环戊烷-S-氧化物与均三甲基溴化镁、双(三甲基硅基)酰胺锂、醛和格氏试剂反应，以良好的收率和高立体选择性得到手性非外消旋胺或亚磺酰胺。

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核心技术专利：CN118964589B侵权必究

School of Chemistry, University of Nottingham, Nottingham NG7 2RD, UK.

J Org Chem. 2011 Nov 18;76(22):9452-9. doi: 10.1021/jo201849j. Epub 2011 Oct 18.

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alpha-Aminoallylation of aldehydes with ammonia: stereoselective synthesis of homoallylic primary amines.

J Am Chem Soc. 2004 Jun 16;126(23):7182-3. doi: 10.1021/ja049689o.

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Acc Chem Res. 2008 Jul;41(7):831-40. doi: 10.1021/ar7002623. Epub 2008 Jun 6.

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Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3037-40. doi: 10.1002/anie.201000652.

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引用本文的文献

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One-pot synthesis of chiral nonracemic amines.

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手性非外消旋胺的一锅合成。

One-pot synthesis of chiral nonracemic amines.

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